Polypeptides of mammalian oncornaviruses. I. Isolation and serological analysis polypeptides from murine and feline C-type viruses |
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| Authors: | Robert W. Green Dani P. Bolognesi Werner Schäfer Liselotte Pister Gerhard Hunsmann Fernando De Noronha |
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| Affiliation: | Duke University Medical Center, Department of Surgery, Durham, North Carolina 27710 U.S.A.;Max-Planck-Institut für Virusforschung Tübingen, Germany;New York State University College, Department of Pathology, Cornell University, Ithaca, New York 14850 U.S.A. |
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| Abstract: | Agents representative of murine and feline C-type viruses contain four major polypeptides of molecular weights 10,000 (P1), 12,000 (P2), 15,000 (P3), and 31,000 (P4). Each was shown to contain distinct antigenic determinants. P1 of Friend leukemia virus (FLV) demonstrates species-specific reactivity different from that present in FLV P4. It also seems to be associated with a host cell component. FLV P2 revealed type or subgroup specificity and was shown to be associated with carbohydrate. FLV P3 was not investigated in as much detail. Feline leukemia virus P4, which is known to contain both species and interspecies determinants, revealed also a type-or subgroup-specific reactivity. Finally, an antiserum prepared against murine P4 was shown to contain antibodies directed against distinguishable interspecies determinants. |
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