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| 7-氯4-{4-[2-(2-甲基咪唑-1-基)-乙基]-哌嗪-1-基}-喹啉的合成与结构鉴定 | |
| 引用本文： | 郭倩仪,彭颖茹,王涛. 7-氯4-{4-[2-(2-甲基咪唑-1-基)-乙基]-哌嗪-1-基}-喹啉的合成与结构鉴定[J]. 广东药学院学报, 2011, 27(4): 361-363. DOI: 10.3969/j.issn.1006-8783.2011.04.007 |
| 作者姓名： | 郭倩仪 彭颖茹 王涛 |
| 作者单位： | 1. 暨南大学药学院,广东广州,510632 2. 广州市医药职业学校,广东广州,510430 3. 广州中医药大学中药学院,广东广州,510006 |
| 摘 要： | 目的 对具潜在抗疟活性的化合物7-氯-4-{4-[2-（2-甲基咪唑-1-基）-乙基]-哌嗪-1-基}-喹啉进行合成设计.方法 采用氨基保护、亲核反应、脱保护等多步反应合成目标产物,并利用硅胶柱层析对其进行纯化.结果 通过GC-MS、IR、1 H-NMR等方法对化合物进行了结构鉴定.结论 本合成方法操作简单,产率高,适... |
| 关 键 词： | 7-氯4-{4-[2-(2-甲基咪唑-1-基)-乙基]-哌嗪-1-基}-喹啉 4-哌嗪基喹啉 结构鉴定 |
Synthesis and structure identification of 7-chloro-4-{ 4-[2-(2-methyl-imidazol-1-yl)ethyl]-piperidine-1-yl } quinoline |
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| GUO Qian-yi,PENG ying-ru,WANG Tao. Synthesis and structure identification of 7-chloro-4-{ 4-[2-(2-methyl-imidazol-1-yl)ethyl]-piperidine-1-yl } quinoline[J]. Academic Journal of Guangdong College of Pharmacy, 2011, 27(4): 361-363. DOI: 10.3969/j.issn.1006-8783.2011.04.007 | |
| Authors: | GUO Qian-yi PENG ying-ru WANG Tao |
| Affiliation: | 1.School of Pharmacy,Jinan University,Guangzhou 510632,China;2.Guangzhou Medical Professional School,Guangzhou 510430,China;3.School of Chinese Herbal Medicine,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006,China) |
| Abstract: | Objective To design and synthesize 7-chloro-4-{4-[2-（2-methyl-imidazol-1-yl） ethyl]-piperidine-1-yl} qinoline,a potential anti-malarial agent.Methods The target compounds were obtained via amino protection,nucleophilic reaction and deprotection,which were purified by silica gel chromatography.Results The products′ structures were characterized by IR,GC-MS and 1H-NMR.Conclusion The synthesis method is feasible with high yields,and can be used for the synthesis of derivatives containing a 4-piperazinyl quinoline ring. |
| Keywords: | 7-chloro-4-{4-[2-（2-methyl-imidazol-1-yl） ethyl]-piperidine-1-yl}qinoline 4-piperidine-quinoline structure identification |
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