辣椒素对寻常型银屑病皮损中P物质及表皮生长因子的作用研究

目的:研究辣椒素对寻常型银屑病的疗效及其作用机制。方法:外用0.025%辣椒素霜6周治疗寻常型银屑病患者26例;用放射免疫方法检测治疗前后皮损中P物质(SP)及表皮生长因子(EGF)的表达。结果:辣椒素霜治疗组治疗后皮损中SP及EGF表达均明显低于治疗前及对照组(均P<0.05);对照组治疗前后皮损中SP及EGF表达均无显著改变(均P>0.05);辣椒素霜治疗组总有效率80.77%,显著高于对照组(总有效率35.00%,P<0.05)。结论:辣椒素通过降低皮损中SP及EGF的表达,抑制表皮角质形成细胞的增殖和真皮血管炎性反应,从而发挥其治疗寻常型银屑病作用。

Effects of topic capsaicin on substance P and epidermal growth factor in the lesions of patients with psoriasis vulgaris

Objective: To investigate whether capsaicin is effective for treating psoriasis vulgaris and explore the therapeutic mechanism. Methods: Patients with psoriasis vulgaris were treated with topic capsaicin cream of 0.025% for 6 weeks. Substance P (SP) and epidermal growth factor (EGF) in the lesions of the patients before and after treatment were detected by radioimmunoassay. Results: The expressions of SP and EGF in the lesions of experimental group post-capsaicin treatment were significantly decreased (all P<0.05) when compared with those pre-capsaicin treatment and those of control group post-placebo treatment. The expressions of SP and EGF in the lesions of control group before and after treatment with placebo had no significant changes (both P>0.05). The overall efficiency of 80.77% in experimental group was significantly higher than that of 35.00% in control (P<0.05). Conclusions: Capsaicin plays a therapeutic role in psoriasis vulgaris through decreasing the expressions of SP and EGF in lesions and subsequently inhibiting the proliferation of keratinocytes and the inflammatory reactions of vessels in derma.