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Gold nanoparticles in delivery applications
Authors:Ghosh Partha  Han Gang  De Mrinmoy  Kim Chae Kyu  Rotello Vincent M
Affiliation:Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
Abstract:
Gold nanoparticles (AuNPs) provide non-toxic carriers for drug and gene delivery applications. With these systems, the gold core imparts stability to the assembly, while the monolayer allows tuning of surface properties such as charge and hydrophobicity. An additional attractive feature of AuNPs is their interaction with thiols, providing an effective and selective means of controlled intracellular release.
Keywords:Gold   Delivery   DNA   Drug delivery   Glutathione   Nanoparticles   Self-assembled monolayer   Photochemistry   Release
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