Interrelationship between coagulation factor VII and obesity in diabetes mellitus (type 2) |
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| Authors: | R.A. Karatela G.S. Sainani |
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| Affiliation: | 1. Heart and Lung Center, Cardiology, Diabetes and Obesity Research Program, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;2. Health Metric, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;3. HUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;4. Department of General Practice and Primary Health Care, University of Helsinki and Health Center of City of Helsinki, Helsinki, Finland;5. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich Heine University, Düsseldorf, Germany;6. German Center for Diabetes Research, Partner Düsseldorf, Germany;7. University of Gothenburg, Gothenburg, Sweden;1. Department of Endocrinology and Metabolism MEA, Aarhus University Hospital, Aarhus, Denmark;2. The Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Copenhagen, Denmark;1. Division of Endocrinology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China;2. Department of Clinical Medicine, West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, China;3. Division of Endocrinology and Metabolism, Chengdu Fifth People''s Hospital, Chengdu, Sichuan 611130, China;4. Chengdu Yincao Community Hospital, Chengdu, Sichuan 611130, China;5. Chengdu Aerospace Hospital, Chengdu, Sichuan 610100, China;6. Laboratory of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China;1. Department of Radiology, Center for Evidence-Based Imaging, Brigham and Women''s Hospital, Harvard Medical School, 20 Kent Street, 2nd Floor, Boston, MA 02445;2. Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women''s Hospital, Harvard Medical School, Boston, Massachusetts |
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| Abstract: | We explored the interrelationships of coagulation FVII activity levels with obesity, leptin and insulin resistance in diabetes mellitus (DM Type 2) and in non-diabetic control subjects. We found FVII hypercoagulant activity levels in DM not associated with obesity, leptin levels or insulin resistance. It was found independently associated with hypertriglyceridemia. |
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