| 糖尿病性心肌病变凋亡相关新基因2ass-bnip3的电子克隆及其功能预测 |
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| 引用本文： | 张芳林,李果,谢超,张迪,周文中,许光武,陈刚,孙卫华,罗敏. 糖尿病性心肌病变凋亡相关新基因2ass-bnip3的电子克隆及其功能预测[J]. 中华内分泌代谢杂志, 2003, 19(4): 325-326 |
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| 作者姓名： | 张芳林 李果 谢超 张迪 周文中 许光武 陈刚 孙卫华 罗敏 |
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| 作者单位： | 200025,上海第二医科大学附属瑞金医院内分泌代谢科,上海市内分泌代谢病研究所 |
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| 基金项目： | 国家 973项目 (G1 9980 51 0 1 7)，国家自然科学基金(30 1 0 0 0 85)，罗氏国际合作项目基金 (2 0 0 1年 )共同资助 |
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| 摘 要： | 对应用荧光标记的mRNA差异显示分析技术筛选获得的2型糖尿病性心肌病变凋亡相关新基因2ass—bnip3，进行全长克隆及其结构／功能预测，获得1594bp的新基因全长及其编码的具187个氨基酸的蛋白2ass—bnip3-p，它可能通过钙调-凋亡调节通路而在糖尿病心肌病变的发生中发挥重要作用。
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| 关 键 词： | 糖尿病性心肌病变 2ass-bnip3 电子克隆 功能 预测 |
| 修稿时间： | 2002-07-02 |
Electronic cloning and functional prediction of new apoptosis related gene 2ass-bnip3 of diabetic cardiomyopathy |
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| ZHANG Fang-lin,LI Guo,XIE Chao,ZHANG Di,ZHOU Wen-zhong,XU Guang-wu,CHEN Gang,SUN Wei-hua,LUO Min. Electronic cloning and functional prediction of new apoptosis related gene 2ass-bnip3 of diabetic cardiomyopathy[J]. Chinese Journal of Endocrinology and Metabolism, 2003, 19(4): 325-326 |
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| Authors: | ZHANG Fang-lin LI Guo XIE Chao ZHANG Di ZHOU Wen-zhong XU Guang-wu CHEN Gang SUN Wei-hua LUO Min |
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| Affiliation: | ZHANG Fang-lin,LI Guo,XIE Chao,ZHANG Di,ZHOU Wen-zhong,XU Guang-wu,CHEN Gang,SUN Wei-hua,LUO Min. Department of Endocrinology and Metabolism Disease,Shanghai Institute of Endocrine and Metabolic Disease,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025 |
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| Abstract: | Using the technique of fluorescent-labled mRNA differential display, new apoptosis related gene 2ass-bnip3 of type 2 diabetic cardiomyopathy was found, the sequence of 1594 bp with coding 187 amino acids was obtained by the full-length clone, and its structural and functional predictions were performed. 2ass-bnip3 may play an important role in the development of diabetic cardiomyopathy via a regulatory pathway of calcium regulation and apoptosis. |
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| Keywords: | Diabetes mellitus Myocardial disease Gene 2ass-bnip3 |
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