E-Cad、MMP9血清中的表达与胃癌痰湿证型关系的临床研究

目的立足于肿瘤转移的生物学特性与痰的病理特征相似基础上,探讨痰在肿瘤转移中发挥作用的可能物质基础。方法以酶联免疫吸附法检测胃癌痰湿证型患者30例治疗前后与非痰湿证型患者32例以及健康对照组10例血清中上皮钙黏附分子(E-Cad)、基质金属蛋白酶(MMP9)的表达;痰湿证组服用消痰散结方1个月,非痰湿证组不治疗。观察治疗前后血清中E-Cad、MMP9的表达变化,并与非痰湿组血清中E-Cad、MMP9的表达进行比较对照。结果两种黏附分子表达在痰湿证型与非痰湿证型中的表达均较健康组升高(P<0.05),痰湿组较非痰湿组升高(P<0.05);治疗组治疗后E-Cad的表达明显降低(P<0.05),MMP9的表达有降低趋势,但差异不显著。结论痰在肿瘤转移中发挥作用的途径可能是通过影响黏附分子的表达,两者存在相关性。

Relationship Between Phlegm Dampness Syndrome of Gastric Cancer and Expressions of E-Cad and MMP9

Objective To observe the material base of phlegm in the tumor metastasis on the basis of the fact that similar biological features of tumor metastasis and pathological features of phlegm. Methods Enzyme-linked immunosorbent assay was adopted to detect E-Cad and MMP9 in 30 cases of gastric cancer of phlegm-dampness syndrome, 32 cases of gastric cancer of non-phlegm-dampness syndrome and 10 healthy people. These 30 cases were treated with "Xiaotan Sanjie Decoction" for one month. The contents of E-Cad and MMP9 were observed and compared. Results E-Cad and MMP9 were higher in patients with gastric cancer than in healthy people, in phlegm-dampness syndrome higher than in non-phlegm-dampness syndrome. Conclusion Phlegm may affect E-Cad and MMP9 in the tumor metastasis.