脑肿瘤术后碳青霉烯类药物联用丙戊酸钠的风险及其解决方案

目的 综述脑肿瘤术后碳青霉烯类药物联用丙戊酸钠后引起丙戊酸钠血药浓度降低的风险，并提出解决方案。方法 通过分析药品说明书，检索并整理碳青霉烯类药物联用丙戊酸钠导致丙戊酸钠血药浓度降低的文献，分析其作用机制，并提出可能的解决方案。结果 说明书和现有文献均认为碳青霉烯类药物可降低丙戊酸钠血药浓度。因此，加强丙戊酸钠血药浓度监测、安全给药剂量研究等将为临床安全应用提供实践依据。结论 脑肿瘤术后碳青霉烯类药物联用丙戊酸钠可降低丙戊酸钠血药浓度，如何实现安全联合用药是下一步研究方向。

Risk and Solutions of Carbapenems Combined with Valproate after Brain Tumor Operation

OBJECTIVE To overview the risk of decreasing the blood drug concentration of valproate caused by the combination carbapenems and valproate after brain tumor operation, and then draw propose solutions. METHODS It analyzed its mechanism and proposes potential solutions by analyzing drug instructions and literatures concerned. RESULTS According to the drug instructions and the existing literatures, carbapenems could decrease the blood drug concentration of valproate. Therefore, more efforts should be made on the research of strengthening the monitor of blood drug concentration of valproate and on dose security would provide practical support for safe clinical application. CONCLUSION Carbapenems can decrease the blood drug concentration of valproate in brain tumor operation treatment combinding carbapenems with valproate. Therefore, how to apply the combination of the drug safely is supposed to be actualized.