苦参碱防治高血糖、高血脂症及其并发症的药理机制研究进展

苦参碱可防治高糖、高脂引起的心血管并发症,脂肪肝并发症,糖尿病视网膜病变,糖尿病肾病以及肺、腹膜纤维化并发症。苦参碱防治这些并发症的药理机制可能是：（1）苦参碱的降血糖、调血脂及抗氧化作用,从源头上减少了氧化型低密度脂蛋白和晚期糖基化终末产物的生成;（2）苦参碱的抗氧化、抗炎和细胞保护作用可保护和修复β细胞,促进胰岛素合成与分泌,也可保护累及的心血管系统、肾脏、肝脏、肺和视网膜等其他器官,减轻胰岛素抵抗,提高胰岛素敏感性。因此,苦参碱有开发成为治疗代谢综合征新药的潜力。

Research progress on pharmacologic mechanism of matrine in treatment for hyperglycemia and hyperlipemia and their complications

Matrine protects and treats for cardiovascular complication, fatty liver complication, diabetic retinopathy, diabetic renopathy, and the complications of lung and peritoneum fibrosis induced by hyperglycystia and hyperliposis. These mechanisms to protect and treat for complications are: (1) the effects of matrine on hypoglycemia, hypolipemia and antioxidation decrease the products of AGEs and ox-LDL from source, (2) the effects on antioxidation, anti-inflammation and cellular protection of matrine protect and repair islet beta cells, improve the synthesis and secretion of insulin, protect suffering organs of cardiovascullar system, ren, liver, lung and retina, alleviate insulin resistance, and increase insulin sensitivity. So matrine has potentiality to become a drug of treating metabolic syndrome.