| 环孢素A对心房颤动犬心房钾通道蛋白Kv1．5的影响 |
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| 引用本文： | 黄亚,卢才义,颜伟,高磊,陈琪,张亚晶. 环孢素A对心房颤动犬心房钾通道蛋白Kv1．5的影响[J]. 心血管康复医学杂志, 2008, 17(6): 519-522 |
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| 作者姓名： | 黄亚 卢才义 颜伟 高磊 陈琪 张亚晶 |
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| 作者单位： | 解放军总医院心研所,北京市,100853 |
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| 基金项目： | 国家自然科学基金 |
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| 摘 要： | 目的：研究环孢素A（CsA）作用下心房颤动犬心房钾离子通道蛋白Kv1．5表达变化。方法：实验犬分为环孢素A干预组（CsA组）、心房纤颤（AF组）及假手术组（Sham组）三个处理组，应用Western免疫印迹技术比较各组间钾离子通道蛋白Kv1．5表达的差异。结果：AF组较Sham组钾通道蛋白Kv1．5表达明显降低（P〈0．01）；CsA组较AF组钾通道蛋白Kv1．5升高（P〈0．01），CsA组与Sham组之间差异不明显（P〉0．05）。结论：CsA逆转了心房颤动犬心房钾离子通道蛋白Kv1．5表达变化，可能会在心房纤颤的治疗中发挥积极的意义。
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| 关 键 词： | 心房颤动 钾通道 环孢素A |
Influence of cyclosporin A on potassium channel protein Kv1.5 of atrium of canine with atrial fibrillation |
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| HUANG Ya,LU Cai-yi,YAN Wei,GAO Lei,CHEN Qi,ZHANG Ya-jing. Influence of cyclosporin A on potassium channel protein Kv1.5 of atrium of canine with atrial fibrillation[J]. Chinese Journal of Cardiovascular Rehabilitation Medicine, 2008, 17(6): 519-522 |
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| Authors: | HUANG Ya LU Cai-yi YAN Wei GAO Lei CHEN Qi ZHANG Ya-jing |
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| Affiliation: | HUANG Ya,LU Cai-yi,YAN Wei,GAO Lei,CHEN Qi,ZHANG Ya-jing:Institute of Geriatric Cardiology,General Hospital of Chinese PLA,Beijing,100853,China |
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| Abstract: | Objective:To investigate the expression change of potassium channel protein Kv1.5 of atrium of canine with atrial fibrillation under the influence of cyclosporin(CsA) A.Methods:Experimental canines are divided into three groups:CsA group,AF group and sham operation group.Western blot technique was used to evaluate the expression of potassium channel protein Kv1.5 among the three groups.Results:Compared to sham operation group,AF groups had reduced expression of potassium channel protein Kv1.5.Compared to AF group,CsA group had increased expression of potassium channel protein Kv1.5(P<0.01) and no significant difference with sham operation group(P<0.05).Conclusion: CsA can significantly improve expression of potassium channel protein Kv1.5. |
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| Keywords: | Atrial fibrillation Potassium channels Cyclosporine A |
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