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| 聚乙二醇单甲醚-聚(D,L-乳酸)嵌段共聚物的研究 | |
| 引用本文： | 邓联东,姚芳莲,孙多先,姚春梅,董岸杰. 聚乙二醇单甲醚-聚(D,L-乳酸)嵌段共聚物的研究[J]. 中国生物医学工程学报, 2005, 24(6): 736-739 |
| 作者姓名： | 邓联东 姚芳莲 孙多先 姚春梅 董岸杰 |
| 作者单位： | 天津大学化工学院,天津,300072 |
| 基金项目： | 国家自然科学基金资助课题（30170227） |
| 摘 要： | 采用熔融缩聚反应合成一系列聚（D，L-乳酸）（PDLLA）／聚乙二醇单甲醚（mPEG）两亲性二嵌段共聚物（PEDLLA），采用IR、^1H-NMR、DSC、WAXD和TEM等手段分析和研究PEDLLA的结构与性能。实验结果表明，PEDLLA的结构和组成与设计相一致，结晶度和熔点均低于均聚物，且随着PEDLLA中PDLLA含量的增加，mPEG嵌段熔点降低，随着PDLLA嵌段相对分子质量的增大，PEDLLA降解速率增大。载药纳米粒呈核壳结构，载药量达30％。 |
| 关 键 词： | 聚（D L-乳酸） 聚乙二醇单甲醚 聚乙二醇单甲醚-b-聚（D L-乳酸） 两亲性共聚物 嵌段共聚物 |
| 文章编号： | 0258-8021(2005)06-0736-04 |
| 收稿时间： | 2003-08-13 |
| 修稿时间： | 2005-11-10 |
Studies on Methoxy Poly( ethylene glycol)-Poly( D, L-lactic acid)block copolymers |
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| DENG Lian-Dong,YAO Fang-Lian,SUN Duo-Xian,YAO Chun-Mei,DONG An-Jie. Studies on Methoxy Poly( ethylene glycol)-Poly( D, L-lactic acid)block copolymers[J]. Chinese Journal of Biomedical Engineering, 2005, 24(6): 736-739 | |
| Authors: | DENG Lian-Dong YAO Fang-Lian SUN Duo-Xian YAO Chun-Mei DONG An-Jie |
| Affiliation: | School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 |
| Abstract: | Amphiphilic diblock copolymers(PEDLLA)were prepared from D,L-lactic acid(DLLA)and methoxy poly(ethylene glycol)(mPEG)by the melting polycondensation.The structure and the properties of copolymers were characterized by IR,~1HNMR,DSC and WAXD respectively.The results showed that the structure and composition of PEDLLA were correspondent with the design,and the crystallinity and T-m were lower than that of the homopolymers,and T-m of mPEG segment decreased upon increasing the content of PDLLA in PEDLLA.The PEDLLA degradative rate increased upon increasing the PDLLA molecular weight.The drug-loaded nanoparticles showed sphere with inner core and outer shell and the drug-loaded amount was more than 25%. |
| Keywords: | poly(D L-lactic acid) methoxy poly(ethylene glycol) methoxy poly(ethylene glycol)-b-poly(D L-lactic acid) amphiphilic copolymer block copolymer |
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