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| 生物材料体内外试验相关性研究--DNA法与肌肉埋植试验的相关性探讨 | |
| 引用本文： | 闻学雷,张彩霞,刘晓亮,顾国珍. 生物材料体内外试验相关性研究--DNA法与肌肉埋植试验的相关性探讨[J]. 生物医学工程学杂志, 2000, 17(4): 444-446 |
| 作者姓名： | 闻学雷 张彩霞 刘晓亮 顾国珍 |
| 作者单位： | 上海生物材料研究测试中心,上海第二医科大学,附属第九人民医院,上海,200023 |
| 基金项目： | 国家自然科基金资助项目!( 3 9410 2 15 ) |
| 摘 要： | 生物材料在医学领域广泛应用，材料的安全性评价是极其重要的一环。研究生物材料体内外试验方法的相关性，以探求与体内动物试验相关性好的体外评价方法。采用体外DNA法与体内肌肉埋植试验对七种生物材料的组织毒性进行了评定，并应用Spearman秩相关统计方法作相关性分析。结果表明：两种方法有良好相关性。 |
| 关 键 词： | 生物材料 DNA法 肌肉埋植试验 相关性 |
Study of the Correlation between in Vitro and in Vivo Evaluation Methods on Biomaterials--DNA Test and Muscular Implant Test |
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| Wen Xuelei,Zhang Caixia,Liu Xiaoliang,Gu Guozhen. Study of the Correlation between in Vitro and in Vivo Evaluation Methods on Biomaterials--DNA Test and Muscular Implant Test[J]. Journal of biomedical engineering, 2000, 17(4): 444-446 | |
| Authors: | Wen Xuelei Zhang Caixia Liu Xiaoliang Gu Guozhen |
| Affiliation: | Shanghai Biomaterial Research & Test Center, Shanghai No. 9 Hospital, Shanghai Second Medical University, Shanghai 200023. |
| Abstract: | With the wide spread use of biomaterials,the safety evaluation on biomaterials has become a very important step.This study on the correlation between DNA test and muscular implant test was done for finding out good in vitro evaluation method.The tissue toxicities of seven biomaterials were examined.Good correlation between DNA test and muscular implant test was demonstrated by Spearman sequential correlation analysis. |
| Keywords: | Biomaterials DNA test Muscular implant test Correlation |
| 本文献已被 维普 万方数据 等数据库收录！ | |