极低出生体重儿呼吸窘迫综合征发病及预后临床分析

目的:探讨影响极低出生体重儿(VLBWI)呼吸窘迫综合征(RDS)发病及预后的高危因素。方法:对新生儿监护病房收治的发生RDS和未发生RDS的VLBWI各47例的临床资料进行回顾性分析。结果:男性、宫内窘迫及出生窒息是RDS的易感因素;有胎膜早破史、产前应用肾上腺皮质激素,生后预防性使用肺表面活性物质可减少RDS发生率;患儿上呼吸机前发生酸中毒和并发动脉导管未闭、肺出血及肺部感染是影响RDS预后的高危因素。结论:VLBWI发生RDS及预后受多因素影响,应避免VLBWI发生RDS的各种易感因素及影响预后的高危因素,采取有效措施减少RDS发生并改善其预后。

Clinical analysis of pathogen and prognosis of respiratory distress syndrome in very low birth weight infants

Objective:To study the critical factors of respiratory distress syntrom(RDS) in very low birth weight infant(VLBWI).Methods:Analyse retrospectively the relative factors of 47 infants respective for suffering from RDS.Results:Boys displayed higher incidence rate than girls.Fetal distress and asphyxia are the risk factors.The incidence was reduced in infant with premature rupture of membrane and using of glucocorticoid and pulmonary surfactant(PS).Acidosis,patent ductus arteriosus,hemorrhagic and infection of lung were the critical factors for prognosis.Conclusions:Multiple factors can influence RDS of VLBWI.It is essential to avoid critical factors and adopt effective steps.