Association of <Emphasis Type="Italic">RGS4</Emphasis> variants with schizotypy and cognitive endophenotypes at the population level期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level

Authors:	Nicholas C Stefanis Thomas A Trikalinos Dimitrios Avramopoulos Nikos Smyrnis Ioannis Evdokimidis Evangelia E Ntzani Alex Hatzimanolis John PA Ioannidis Costas N Stefanis

Affiliation:	(1) University Mental Health Research Institute, Athens, Greece;(2) Department of Psychiatry, National and Kapodistrian University of Athens, Greece;(3) Department of Psychological Medicine, King's College London, Institute of Psychiatry, London, UK;(4) Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece;(5) Department of Medicine, Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, Mass, USA;(6) Foundation for Research and Technology-Hellas, Biomedical Research Institute, Ioannina, Greece

Abstract:	Background While association studies on schizophrenia show conflicting results regarding the importance of the regulator of the G-protein signaling 4 (RGS4) gene, recent work suggests that RGS4 may impact on the structural and functional integrity of the prefrontal cortex. We aimed to study associations of common RGS4 variants with prefrontal dependent cognitive performance and schizotypy endophenotypes at the population level.

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