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Impact of Weight Loss During Chemotherapy in Chinese Patients with Unresectable Pancreatic Cancer |
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| Authors: | Henry C. Y. Wong Kwan Y. Lam Charing C. N. Chong Anthony W. H. Chan |
| Affiliation: | 1. Department of Oncology, Princess Margaret Hospital, Hong Kong;2. Department of Clinical Oncology, Sir YK Pao Center for Cancer, Prince of Wales Hospital, Hong Kong;3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong;4. Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong;5. State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong, Hong Kong |
| Abstract: | Background: Weight loss is frequently observed in pancreatic cancer patients. We aimed to study the prognostic impacts of weight loss early during chemotherapy. Methods: A total of 72 patients of Chinese ethnicity with unresectable pancreatic cancer who underwent chemotherapy were reviewed. Critical weight loss (CWL) was defined as weight loss ≥ 5% within one month after treatment. The prognostic impact of weight loss and CWL were analyzed. Results: 47 patients (65.3%) had weight loss after one month of treatment, with 14 (19.4%) suffering from CWL. Baseline characteristics were similar between patients with and without CWL. The median OS and Time-to-treatment-failure (TTF) of patients with CWL were shorter than those without CWL (OS: 4.8?months [CWL] versus [vs.] OS 7.1?months [No CWL]; TTF 1.6?months [CWL] vs. 3.2?months [No CWL]; both P?P?=?0.01) and TTF (HR = 2.71; P?P? Conclusions: Development of CWL in early course of chemotherapy was associated with worse prognosis in Chinese patients with unresectable pancreatic cancers. |
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