Antitumor Action of Amygdalin on Human Breast Cancer Cells by Selective Sensitization to Oxidative Stress |
| |
| Authors: | Muayad Mehdi Abboud Wajdy Al Awaida Hakam Hasan Alkhateeb Asia Numan Abu-Ayyad |
| |
| Affiliation: | 1. Department of Basic Medical Sciences, Faculty of Medicine, Hashemite University, Zerga, Jordan;2. Department of Biology and Biotechnology, Faculty of Sciences, American University of Madaba, Madaba, Jordan;3. Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan;4. Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Hashemite University, Zerga, Jordan |
| |
| Abstract: | The treatment of MCF-7 and T47D human breast cancer cell lines with amygdalin was able to reduce the growth of both cells, in concentration and time-dependent manners. The potency of this inhibition against MCF-7 and T47D cells produced IC50 values of 39 and 45?mM, respectively. To investigate the correlation of this inhibition with oxidative stress, an amygdalin treatment of both cell lines was capable of inducing the generation of malondialdehyde (MDA) and oxidized glutathione levels. Also, this treatment caused the decrease of total glutathione and glutathione reductase activity. The proportional survival of tumor cells from this inhibition was positively correlated with the total glutathione, but it was inversely correlated with amygdalin or MDA levels (P?
|
| |
| Keywords: | |
|
|
