超短波联合电针疗法对家兔膝关节骨性关节炎自由基代谢的影响

目的观察超短波联合电针对家兔实验性膝关节骨性关节炎的治疗作用并探讨其机制。方法将55只日本大耳白兔随机分出10只为空白对照组,余45只采用右后肢膝关节伸直位固定6周的方法建立膝关节骨性关节炎模型。将造模成功的40只家兔随机分为模型对照组、电针治疗组、超短波治疗组、联合治疗组,每组10只。电针治疗组选取家兔右后肢血海、梁丘、阳陵泉和足三里穴,毫针针刺后接电针治疗仪治疗25min,超短波治疗组使用超短波机治疗20min,联合治疗组联合采用电针和超短波治疗,各组均每日治疗1次,在治疗30天后测定兔血清超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)的含量以及测量家兔右后肢膝关节活动度。结果电针治疗组、超短波治疗组、联合治疗组同模型对照组比较血清中SOD显著升高,NO、MDA显著降低,关节活动度改善(P0.01);并且联合治疗组优于超短波治疗组和电针治疗组(P0.01)。结论超短波联合电针治疗家兔膝关节骨性关节炎疗效肯定并优于单纯的超短波疗法和电针疗法,其作用机制可能与改善自由基代谢有关。

Effect of Ultrashort-wave Therapy Combined with Electroacupuncture on Metabolism of Free Radicals in Rabbits with Knee Osteoarthritis

Objective To investigate the therapeutic effect and mechanism of ultrashort-wave therapy combined with electroacupuncture on the experimental rabbits with knee osteoarthritis.Methods Ten of fifty-five experimental Japanese big-ear rabbits were randomized into the blank control group, and the other 45 were made knee osteoarthritis models by prolonged fixation of the right posterior knee joint in extension for 6 weeks. The 40 successfully made models were randomized into model control group, electroacupunctur...