Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro |
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Authors: | Tatiana M. Korotkova Helmut L. Haas Ritchie E. Brown |
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Affiliation: | Institute for Neurophysiology, Heinrich Heine University, D-40001, Duesseldorf, Germany |
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Abstract: | We have investigated the effect of histamine (HA) on spontaneous firing of dopaminergic (DA) and GABAergic neurons in the substantia nigra (SN) and the ventral tegmental area (VTA) of the rat in vitro. Single-unit extracellular recordings were obtained and drugs were bath applied. In both regions application of HA (10 and 100 μM) did not affect the firing frequency of DAergic cells, but increased the firing of GABAergic neurons. The histamine-induced excitation was blocked by the H1 receptor antagonist mepyramine (1 μM), but was unaffected by application of the H2 antagonist cimetidine (50 μM) or the H3 antagonist thioperamide (10 μM). Our results suggest that histamine does not directly inhibit dopaminergic neurons in SN and VTA, but rather that this inhibition is mediated through histamine-induced excitation of GABAergic neurons. |
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Keywords: | Dopamine Tuberomammillary nucleus Reinforcement Mepyramine In vitro Single-unit |
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