健脾祛湿颗粒口服配合消炎止痒洗剂湿敷治疗湿疹的疗效观察

目的 观察健脾祛湿颗粒口服配合消炎止痒洗剂湿敷治疗湿疹的临床疗效.方法 将90例湿疹患者随机分为治疗组和对照组,各45例,治疗组采用本科自制的健脾祛湿颗粒,每天一剂,分早晚两次温水冲服,配合消炎止痒洗剂：将20 g药粉加2000 ml温开水浸泡20 min,待冷却至室温后,将5～6层纱布浸渍于药液中片刻后取出,拧至不滴水后湿敷患处,每次20 min,每天2～3次.对照组采用莫匹罗星软膏联合糠酸莫米松乳膏外用治疗.两组均治疗30天,观察两组治疗前后瘙痒程度、皮疹形态、皮疹面积积分及总积分,并比较两组临床疗效和治疗期间出现的不良反应.结果 治疗后,治疗组的皮疹形态、皮疹面积积分均低于对照组,经比较差异有统计学意义（P＜ 0.05,P＜ 0.01）,对照组瘙痒程度积分高于治疗组,经比较差异有统计学意义（P＜0.05）,而两组的总积分比较差异无统计学意义（P＞ 0.05）;治疗组总有效率为86.7％,对照组为77.7％,经Riddt分析,差异无统计学意义（u=-1.590,P＞ 0.05）;治疗组中总共有3例出现皮肤灼痛感及色素沉着不良反应,而对照组出现8例.结论 健脾祛湿颗粒口服配合消炎止痒洗剂湿敷治疗湿疹与莫匹罗星软膏联合糠酸莫米松乳膏外用治疗相比,总体疗效相当,但前者在改善患者皮疹形态和皮疹面积方面优于后者,且不良反应相对较少,不失为临床上治疗湿疹的一种可选方案.

Observation of curative effect of oral particles medicine of spleen-strengthening and damp-removing concomitant with antiphlogistic and antipruritic lotion wet dressing in the treatment of eczema

Objective To observe the curative effect of oral particles medicine of spleenstrengthening and damp-removing concomitant with antiphlogistic and antipruritic lotion wet dressing in the treatment of eczema.Methods 90 cases of eczema were randomly divided into treatment group and control group,45 cases in each group.Treatment group was given the treatment of self-made spleen-strengthening and damp-removing particles medicine,one dose a day,infused with warm water twice a day in the morning and night,and combined with antiphlogistic and antipruritic lotion：20 g powder soaked with 2000 ml warm water for 20 min,after cooling to room temperature,5-6 layers of gauze dipped in the liquid for a moment,when the gauze didn＆#39; t drip wetted the affected area about 20 minutes,2-3 times a day.Control group was given the treatment of topical mupirocin ointment combined mometasone furoate cream.The treatment lasted for 30 days.Observed scores of pruritus,rash form,rash area and total score in two groups before and after the treatment,at the same time compared the clinical efficacy and adverse reactions occurred during the treatment.Results After treatment,scores of rash form and rash area in treatment group were lower than those in control group,with statistically significant differences （P 〈 0.05 or P 〈 0.01）; pruritus score in treatment group was higher than that in control group,with statistically significant difference （P 〈 0.05）; there was no statisticallysignificant difference in total score between two groups （P 〉 0.05）.The total effective rate in treatment group was 86.7%,while that in control group was 77.7%,without statistically significant difference （u =-1.590,P 〉 0.05）.There were 3 cases of skin burning sensation and pigmentation in treatment group,8 cases in control group.Conclusions Oral particles medicine of spleen-strengthening and damp-removing concomitant with antiphlogistic and antipruritic lotion wet dressing in the treatment of eczema had the same overall effect as the treatment of topical mupirocin ointment combined with mometasone furoate cream,but the former was better in improving patients＆#39; rash form and area with fewer adverse reactions,which could be an alternative in the clinical treatment of eczema.