| 钩藤碱和异钩藤碱对~(45)Ca转运的影响 |
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| 引用本文： | 黄燮南,石京山.钩藤碱和异钩藤碱对~(45)Ca转运的影响[J].中国药理学通报,1993,9(6):428-430. |
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| 作者姓名： | 黄燮南 石京山 |
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| 作者单位： | 遵义医学院药理教研室 贵州563003
(黄燮南，石京山，谢笑龙，张炜)，遵义医学院药理教研室 贵州563003(朱毅) |
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| 摘 要： | 在离体家兔主动脉条.钩藤碱和异钩藤碱明显减少KCl(77.0 mmol·L~(-1))溶液所致45Ca内流量、不影响去甲肾上腺素所引起的45Ca内流和外溢。结果表明.钩藤碱和异钩藤碱对电位依赖性钙通道具有阻滞作用。
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| 关 键 词： | 钩藤碱 异钩藤碱 ~(45)Ca内流 血管平滑肌 电位依赖性钙通道 |
Effects of Rhynchophylline and Isorhynchophylline on the (45)~Ca-transportation in rabbit aorta |
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| HUANG Xie-Nan,SHI Jin-Shan,XIE Xiao-Long et al.Effects of Rhynchophylline and Isorhynchophylline on the (45)~Ca-transportation in rabbit aorta[J].Chinese Pharmacological Bulletin,1993,9(6):428-430. |
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| Authors: | HUANG Xie-Nan SHI Jin-Shan XIE Xiao-Long |
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| Abstract: | The effects of Rhynchophylline (Rhy) and Isorhychophyiline (Isorhy), the alkaloids abstracted from the Chinese traditional herb Uncaria rhynchophyllia (Miq) Jackson, on the 45Ca-influx and efflux were investigated in rabbit aorta. Both Rhy and Isorhy (10 μmol· L-1) inhibited the 45Ca-influx induced by high K+(77. 0 mmol · L-1), but neither significant-
ly influenced the 45Ca-influx and efflux induced by noradrenaline (10 μmol · L-1). The results suggest that these alkaloids block the Voltage-dependent calcium channel. |
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| Keywords: | Rhynchophylline Isorhynchophylline (45)~Ca-influx voltage-dependent Ca~(2+) channel vascular smooth muscle |
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