| 美洲大蠊提取物对3株人体呼吸系统肿瘤细胞的细胞毒性研究 |
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| 引用本文： | 何正春,王晓雨,胡明辉,赵昱,刘光明.美洲大蠊提取物对3株人体呼吸系统肿瘤细胞的细胞毒性研究[J].中国现代药物应用,2009,3(7):1-2. |
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| 作者姓名： | 何正春 王晓雨 胡明辉 赵昱 刘光明 |
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| 作者单位： | 1. 云南省大理学院药学院,671000
2. 浙江大学药学院 |
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| 摘 要： | 目的通过2对美洲大蠊提取物的肿瘤细胞毒性测试，探讨美洲大蠊提取物的抗肿瘤作用。方法美洲大蠊醇提取物，通过聚酰胺柱层析分离划段得不同部位，采用MTT法对所得部位进行肿瘤细胞毒性测试。结果有多个部位样品的IC50值小于10μg/ml。结论通过样品与对照品细胞毒活性结果比较，表明美洲大蠊提取物中存在具有肿瘤细胞生长抑制作用的物质，值得对其进行进一步的研究。
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| 关 键 词： | 美洲大蠊 提取物 聚酰胺 MTT 细胞毒 |
Study on respiratory system tumor cell cytotoxicity of extracts from periplaneta americana |
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| Institution: | HE Zheng- chun, WANG Xiao-yu, HU Ming-hui ,et al. (Pharmaceutical Department of Yunnan College ,Dali 671000, China) |
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| Abstract: | Objective To study the anti-tumor activity of extracts from Periplaneta americana by cytotoxicity assay on respiratory system tumor cell （ CNE, A549, KB）. Methods The samples prepared with polyamide column chromatography separation of extracts from Periplaneta americana and the cytotoxicity of samples assessed with MTT assaying. Results There are several samples have strong cytotoxicity and some of them have IC50 lower than 10 μg/ml on cell that we assaied. Conclusion There are anti-tumor activity compounds in extracts of periplaneta americana by comparison the cytotoxicity results between samples and DDP and to be worth research further. |
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| Keywords: | Periplaneta americana Extracts Polyamide MTT Cytotoxicity |
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