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| 诱导型一氧化氮合酶在创伤性脑损伤后肠黏膜屏障损伤中表达的变化 | |
| 引用本文： | 吕栋,崔培林,徐有青,杨昭徐. 诱导型一氧化氮合酶在创伤性脑损伤后肠黏膜屏障损伤中表达的变化[J]. 山东医药, 2011, 51(20): 8-9,25 |
| 作者姓名： | 吕栋 崔培林 徐有青 杨昭徐 |
| 作者单位： | 首都医科大学附属北京天坛医院,北京,100050 |
| 基金项目： | 首都医学发展科研基金资助项目(2007-3098) |
| 摘 要： | 目的观察创伤性脑损伤（TBI）后肠黏膜屏障损伤时诱导型一氧化氮合酶（iNOS）表达的变化及其可能的作用。方法 48只健康雄性W istar大鼠随机分为TBI组（n=24）和对照组（n=24）,各组动物分别在手术后3、6、12、24 h处死,每个时间点6只。动物处死后,抽门静脉血测血清内毒素、二胺氧化酶（DAO）,取脑组织和回肠黏膜,观察组织形态学改变,并测定肠黏膜组织DAO的含量和iNOS的表达情况。结果 TBI组肠黏膜受损,血中内毒素含量增加（P〈0.05）;肠黏膜DAO活性下降（P〈0.01）,而血中DAO活性则升高（P〈0.05）;iNOS的表达3h已经增高,12h达到最高,而后逐渐降低,但仍然高于对照组（P〈0.05）。结论 iNOS在TBI后肠黏膜屏障损伤时表达明显增加,参与了TBI后肠黏膜屏障损伤。 |
| 关 键 词： | 创伤性脑损伤 肠黏膜屏障 一氧化氮合酶 |
Expression of inducible nitric oxide synthase in intestinal mucosa barrier dysfunction following traumatic brain injury in rats |
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| LV Dong,CUI Pei-lin,XU You-ging,YANG Zhao-xu. Expression of inducible nitric oxide synthase in intestinal mucosa barrier dysfunction following traumatic brain injury in rats[J]. Shandong Medical Journal, 2011, 51(20): 8-9,25 | |
| Authors: | LV Dong CUI Pei-lin XU You-ging YANG Zhao-xu |
| Affiliation: | LV Dong,CUI Pei-lin,XU You-qing,YANG Zhao-xu (Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,P.R.China) |
| Abstract: | Objective To observe the expression of inducible nitric oxide synthase(iNOS) protein on intestinal mucosal barrier dysfunction following traumatic brain injury(TBI),and explore its possible mechanism.Methods Forty-eight male Wistar rats were randomly divided into TBI group and control group.During the experiment period,the morphological changes of intestinal mucosa were observed,and the intestinal mucosal permeability was detected by measuring the levels of endotoxin and diamine oxidase(DAO).iNOS protein wa... |
| Keywords: | traumatic brain injury intestinal mucosal barrier inducible nitric oxide synthase |
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