| 结直肠癌发生机制研究进展 |
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| 引用本文： | 陈慧. 结直肠癌发生机制研究进展[J]. 胃肠病学, 2013, 18(3): 188-190 |
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| 作者姓名： | 陈慧 |
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| 作者单位： | 陈慧 (中山大学孙逸仙纪念医院消化内科,510120)； |
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| 摘 要： | 结直肠癌是最常见的恶性肿瘤之一，其发生由遗传和环境等诸多因素相互作用所致，是一个涉及多基因、多阶段的复杂过程。本文就结直肠癌发生机制包括染色体不稳定（CIN）、微卫星不稳定（MSI）、CpG岛甲基化表型（CIMP）等的研究进展作一综述。
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| 关 键 词： | 结直肠肿瘤 分子作用机制 治疗 |
Advances in Study on Pathogenesis of Colorectal Cancer |
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| Affiliation: | CHEN Hui, ZHAN Jun. (Department of Gastroenterology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou (510120)) |
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| Abstract: | Colorectal cancer is one of the most common malignant tumors. The genesis of colorectal cancer is the result of interaction between genetic and environmental factors, and is a muhi-gene, multi-step process. This article reviewed the advances in study on pathogenesis of colorectal cancer, including chromosome instability （CIN）, microsatellite instability （MSI） and CpG island methylator phenotype （CIMP）. |
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| Keywords: | Colorectal Neoplasms Molecular Mechanisms of Action Therapy |
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