原发性醛固酮增多症的靶器官损害及治疗

原发性醛固酮增多症(PA)是继发性高血压的常见病因,也是顽固性高血压的原因之一。由于高醛固酮血症及低肾素活性的影响,水钠潴留及血管内皮的炎症改变导致血压升高,动脉硬化及心脏、脑、肾脏靶器官损害,使心血管事件的发生率增加。关于PA患者的治疗,降低血压、治疗高醛固酮血症、盐皮质激素受体、手术及醛固酮受体拮抗剂的应用都是有效的方法,有助于减少患者的心血管疾病风险。

Target Organ Damage and Treatment of Primary Aldosteronism

Primary aldosteronism（PA） is a common cause of secondary hypertension,which is also one of the causes of intractable hypertension. The hyperaldosteronemia and low renin activity can lead to water natri- urn retention and vascular endothelial inflammation change, which all can lead to higher blood pressure, and even cause arteriosclerosis and damages of the target organs of heart, brain and kidney, leading to the increase of the incidence of cardiovascular events. Lowering blood pressure, treatment of hyperaldosteronism and incre asing mineralocorticoid receptor, surgery and mineralocorticoid receptor antagonist are all effective treatments for PA,whieh can help to reduce the risk of cardiovascular diseases.