| RANK/RANKL/OPG信号通路的研究进展 |
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| 引用本文： | 王琰,刘超,宋仁纲. RANK/RANKL/OPG信号通路的研究进展[J]. 医学综述, 2013, 19(7): 1166-1168 |
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| 作者姓名： | 王琰 刘超 宋仁纲 |
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| 作者单位： | 王琰 (哈尔滨医科大学附属第一医院骨一科,哈尔滨,150000)；刘超 (哈尔滨医科大学附属第一医院骨一科,哈尔滨,150000)；宋仁纲 (秦皇岛市山海关人民医院骨一科,秦皇岛,066200)； |
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| 摘 要： | 核因子κB受体活化因子/核因子κB受体活化因子配体/骨保护素(RANK/RANKL/OPG)信号通路是近些年来骨代谢领域的重大发现。许多激素、细胞因子、生长因子通过作用于核因子κB受体活化因子配体,骨保护素影响骨代谢,而导致骨代谢疾病如骨质疏松,溶骨性骨肿瘤及恶性肿瘤骨转移等。该文就主要RANK/RANKL/OPG信号通路的成员、信号转导及表达调控进行综述。
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| 关 键 词： | 核因子κB受体活化因子 核因子κB受体活化因子配体 骨保护素 核因子κB受体活化因子/核因子κB受体活化因子配体/骨保护素信号转导 逆信号 |
Research Progress of RANK/RANKL/OPG Signaling Pathway |
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| WANG Yan,LIU Chao,SONG Ren-gang,ZHANG Zhen-yu. Research Progress of RANK/RANKL/OPG Signaling Pathway[J]. Medical Recapitulate, 2013, 19(7): 1166-1168 |
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| Authors: | WANG Yan LIU Chao SONG Ren-gang ZHANG Zhen-yu |
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| Affiliation: | WANG Yan ,LIU Chao ,SONG Ren- gang ,ZHANG Zhen-yu ( 1. First Department of Orthopedics, Harbin Medical University First Affiliated Hospital,Harbin 150000, China; 2. First Department of Orthopedics, Qinhuangdao Shanhaiguan People＇s Hospital, Qinhuangdao 066200, China) |
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| Abstract: | The RANK/RANKL/OPG signaling pathway is an important discovery of bone metabolism in recent years. A lot of hormones, cytokines, growth factors influence bone metabolism by acting on receptor activator of NF-κ B ligand（RANKL） and osteoprotegerin（OPG） ,which lead to metabolic bone diseases such as osteoporosis, osteolytic bone tumors and malignant tumor bone metastasis. Here is to make a review on the member, signal transduction and regulation of expression of RANK/RANKL/OPG signaling pathway. |
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| Keywords: | Receptor activator of NF-κ B Receptor activator of NF-κB ligand Osteoprotegerin RANK/RANKL/OPG signal transduction Reverse signal |
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