| Toll样受体3与自身免疫性内分泌疾病 |
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| 引用本文： | 李庆欣,李兰英. Toll样受体3与自身免疫性内分泌疾病[J]. 国际内分泌代谢杂志, 2008, 28(3) |
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| 作者姓名： | 李庆欣 李兰英 |
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| 作者单位： | 卫生部及天津市激素与发育重点实验室,天津医科大学内分泌研究所,300070 |
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| 基金项目： | 天津市教委资助项目，天津市科技发展基金 |
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| 摘 要： | Toll样受体(TLR)3可识别病毒dsRNA或其人工合成类似物聚肌苷酸聚胞苷酸[Poly(I:C)]和宿主来源的mRNA,通过髓样细胞分化因子(MyD)88依赖型和MyD88非依赖型两种信号通路,激活固有免疫,并为激活适应性免疫提供共刺激信号.TLR3在自身免疫性疾病尤其是在1型糖尿病和自身免疫性甲状腺疾病的发生、发展中起重要作用,该作用主要是通过Ⅰ型干扰素(IFN)介导实现的.
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| 关 键 词： | Toll样受体3 1型糖尿病 自身免疫性甲状腺疾病 |
Toll-like receptor 3 and autoimmune endocrine diseases |
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| LI Qing-xin,LI Lan-ying. Toll-like receptor 3 and autoimmune endocrine diseases[J]. International JOurnal of Endocrinology and Metabolism, 2008, 28(3) |
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| Authors: | LI Qing-xin LI Lan-ying |
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| Abstract: | Studies show that Toll-like receptor 3 (TLR3) responds not only to double stranded (ds) RNA and polyinosinic-polycytidylic acid[ Poly( I: C ) ], a chemical analog of viral dsRNA, but also to host-derived mRNA. In respond to its ligands, TLR3 activates innate immunity and provides costimulatory molecules for adaptive immunity by two different pathways, a myeloid differentiation factor (MyD)88-dependent pathway and a MyD88-independent pathway. TLR3 plays an important role in the development of autoimmune diseases,mainly by type Ⅰ interferon (IFN) production, especially in type 1 diabetes and autoimmune thyroid diseases. |
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| Keywords: | TLR3 Type 1 diabetes mellitus Autoimmune thyroid diseases |
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