Serum Levels of Maprotiline and Its Adverse Effects on Depressed Patients |
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| Authors: | Kouichi Kurata M.D. Hideki Kido M.D. Mitsuru Hasegawa M.D. Masao Inoue M.D. Nariyoshi Yamaguchi M.D. |
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| Affiliation: | Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama;*Department of Neuropsychiatry, Kanazawa University School of Medicine, Kanazawa |
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| Abstract: | ![]()
Abstract: The relationships between the side effects of maprotiline (MPT) andthe serum concentration of MPT and desmethylmaprotiline (DMPT) were investigated with 27 blood samplings in 15 depressed inpatients. There were significant correlations between the side effects and serum levels of MPT and DMPT. Mild side effects frequently occurred at levels of more than 130 ng/ml of MPT and 70 ng/ml of DMPT. At more than 220 ng/ml of the MPT levels and 110 ng/ml of DMPT levels, severe side effects occurred. Nearly sigmoidalserum level/side effect response curves occurred with both compounds. |
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| Keywords: | maprotiline desmethylmaprotiline side effect dose correlation |
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