Immune signaling pathways activated in response to different pathogenic micro-organisms in Bombyx mori |
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| Affiliation: | 1. School of Biology & Basic Medical Science, Soochow University, Suzhou 215123, China;2. National Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China;1. Department of Entomology, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, China;2. Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA;3. Key Laboratory of Plant Protection Resources and Pest Management, Ministry of Education, Northwest A&F University, Yangling, Shaanxi 712100, China;1. Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA;2. Boyce Thompson Institute, Cornell University, Ithaca, NY 14853, USA;3. Division of Biology, Kansas State University, Manhattan, KS 66506, USA;4. Department of Biology, University of Massachusetts, Amherst, MA 01003, USA;1. College of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212018, China;2. The Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang 212018, China;1. Key Laboratory of Biology and Sustainable Management of Plant Diseases and Pests of Anhui Higher Education Institutes, School of Plant Protection, Anhui Agricultural University, Hefei, China;2. Anhui Province Key Laboratory of Integrated Pest Management on Crops, Hefei, China |
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| Abstract: | The JAK/STAT, Toll, Imd, and RNAi pathways are the major signaling pathways associated with insect innate immunity. To explore the different immune signaling pathways triggered in response to pathogenic micro-organism infections in the silkworm, Bombyx mori, the expression levels of the signal transducer and activator of transcription (BmSTAT), spatzle-1 (Bmspz-1), peptidoglycan-recognition protein LB (BmPGRP-LB), peptidoglycan-recognition protein LE (BmPGRP-LE), argonaute 2 (Bmago2), and dicer-2 (Bmdcr2) genes after challenge with Escherichia coli (E. coli), Serratiamarcescens (Sm), Bacillus bombyseptieus (Bab), Beauveriabassiana (Beb), nucleopolyhedrovirus (BmNPV), cypovirus (BmCPV), bidensovirus (BmBDV), or Nosemabombycis (Nb) were determined using real-time PCR. We found that the JAK/STAT pathway could be activated by challenge with BmNPV and BmBDV, the Toll pathway could be most robustly induced by challenge with Beb, the Imd pathway was mainly activated in response to infection by E. coli and Sm, and the RNAi pathway was not activated by viral infection, but could be triggered by some bacterial infections. These findings yield insights into the immune signaling pathways activated in response to different pathogenic micro-organisms in the silkworm. |
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| Keywords: | Silkworm JAK/STAT pathway Toll pathway Imd pathway RNAi pathway Innate immunity |
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