Potassium-induced release of tritiated histamine from rat brain tissue slices. |
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| Authors: | N Subramanian A H Mulder |
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| Affiliation: | Department of Pharmacology, Mount Sinai School of Medicine of the City University of New York, Fifth Ave. and 100 St. New York, N.Y. 10029, U.S.A. |
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| Abstract: | The release of exogenous histamine was studied by superfusing brain slices following incubation with the radiolabeled amine. Histamine was released in a calcium-dependent way by 40 mM potassium. This release was high in hypothalamus and striatum and low in hippocampus and cortex. Compound 48/80, a mast cell histamine releasing agent, also induced histamine release, but only from hypothalamic tissue slices. It is suggested that the potassium-induced release of accumulated exogenous histamine is mainly from glial cells. |
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| Keywords: | 3,4-Dihydroxyphenylacetic acid Homovanillic acid Dopamine Striatum Clozapine Nucleus accumbens |
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