Burden of neurological conditions in Canada |
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| Affiliation: | 1. McLaughlin Center for Population Health Risk Assessment, University of Ottawa, Ottawa, ON, Canada;2. Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, ON, Canada;3. Environmental Health Research Unit, University of Ottawa, ON, Canada;4. Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, ON, Canada;5. Risk Sciences International, Ottawa, ON, Canada;1. Department of Urology, Ghent University Hospital, Ghent, Belgium;2. Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium;3. Department of Medical Oncology, University Hospital Leuven, Leuven, Belgium;4. Department of Medical Oncology, AZ Turnhout, Turnhout, Belgium;5. Department of Medical Oncology, AZ Klina, Kalmthout, Belgium;6. Department of Medical Oncology, AZ Delta, Roeselare, Belgium;7. Department of Medical Oncology, Imelda Hospital, Bonheiden, Belgium;8. Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium;9. Department of Urology, Onze-Lieve-Vrouw Hospital, Aalst, Belgium;10. Department of Medical Oncology, Hopital De Jolimont, Haine Saint Paul, Belgium;11. Department of Medical Oncology, University Hospital Brussels, Jette, Belgium;12. Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint Luc, Brussels, Belgium;13. Department of Medical Oncology, Ziekenhuis Netwerk Antwerpen (ZNA) Middelheim, Antwerp, Belgium;14. Department of Medical Oncology, AZ Nikolaas, Sint-Niklaas, Belgium;15. Department of Medical Oncology, CHU Dinant-Godinne, Yvoir, Belgium;16. Department of Urology, AZ Groeninge, Kortrijk, Belgium;17. Department of Medical Oncology, ZNA Jan Palfijn, Merksem, Belgium;18. Department of Medical Oncology, AZ Jessa, Hasselt, Belgium;19. Department of Medical Oncology, St Luc Bouge, Namur, Belgium;20. Department of Medical Oncology, UZA/AZ Monica, Antwerp, Belgium;21. Department of Medical Oncology, Algemeen Stedelijk Ziekenhuis, Aalst, Belgium;22. Department of Medical Oncology, AZ Sint-Trudo, Sint-Truiden, Belgium;23. Department of Urology, AZ Sint-Andries, Tielt, Belgium;24. Department of Medical Oncology, Sainte-Elisabeth, Namur, Belgium;1. Sydney Adventist Hospital, 185 Fox Valley Road, Wahroonga, Sydney, NSW 2076, Australia;2. University of Sydney, Sydney, NSW 2006, Australia;1. Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland;2. School of Geography, Planning and Environmental Policy, University College Dublin Belfield, Dublin, Ireland;3. School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland;4. Department of Neurology, Beaumont Hospital, Beaumont, Ireland |
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| Abstract: | Neurological conditions are among the leading causes of disability in the Canadian population and are associated with a large public health burden. An increase in life expectancy and a declining birth rate has resulted in an aging Canadian population, and the proportion of age-adjusted mortality due to non-communicable diseases has been steadily increasing. These conditions are frequently associated with chronic disability and an increasing burden of care for patients, their families and caregivers. The National Population Health Study of Neurological Conditions (NPHSNC) aims to improve knowledge about neurological conditions and their impacts on individuals, their families, caregivers and health care system. The Systematic Review of Determinants of Neurological Conditions, a specific objective within the NPHSNC, is a compendium of systematic reviews on risk factors affecting onset and progression of the following 14 priority neurological conditions: Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), brain tumours (BT), cerebral palsy (CP), dystonia, epilepsy, Huntington’s disease (HD), hydrocephalus, multiple sclerosis (MS), muscular dystrophies (MD), neurotrauma, Parkinson’s disease (PD), spina bifida (SB), and Tourette’s syndrome (TS). The burden of neurological disease is expected to increase as the population ages, and this trend is presented in greater detail for Alzheimer’s and Parkinson’s disease because the incidence of these two common neurological diseases increases significantly with age over 65 years. This article provides an overview of burden of neurological diseases in Canada to set the stage for the in-depth systematic reviews of the 14 priority neurological conditions presented in subsequent articles in this issue. |
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| Keywords: | Neurological conditions Disease burden Prevalence Incidence Systematic review Onset Progression Risk factors |
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