Serum C-peptide as a key contributor to lipid-related residual cardiovascular risk in the elderly |
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| Institution: | 1. Department of Social Medicine, School of Public Health, Zhejiang University, China;2. School of Basic Medical Sciences, Zhejiang University, China;1. Research Education and Epidemiology Center, Changhua Christian Hospital, No. 135, Nan-Hsiao Street, Changhua 500-06, Taiwan, ROC;2. Institute of Gerontology, National Cheng Kung University, No. 1, University Road, Tainan City 701, Taiwan, ROC;1. Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan;2. Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan;3. Research Institute, National Center for Geriatrics and Gerontology, 35 Gengo, Morioka-machi, Obu-shi, Aichi 474-8511, Japan;4. East-West Medical Research Institute, Kyung Hee University, 23, Kyung Hee Dae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea;1. Research and Education Unit on Ageing (UNIFAI/ICBAS-UP), University of Porto, Porto, Portugal;2. Faculty of Medicine, University of Porto (FMUP-UP), Porto, Portugal;3. Center for Health Technology and Services Research (CINTESIS), Porto, Portugal;1. Faculty of Health Sciences, Mejiro University, 320 Ukiya Iwatuki-ku Saitama-shi Saitama, 339-8501, Japan;2. Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan;3. Department of Allied Health Science. Kitasato University, Sagamihara-shi Kanagawa, Japan;1. Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany;2. Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University of Duisburg-Essen, Essen, Germany;3. Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria;4. Institute of Medical Biometry and Statistics (IMBS), University of Lübeck, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany;5. Medizinische Klinik II, St. Vincenz-Krankenhaus, Datteln, Germany;6. IUF Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany;7. Department of Epileptology, University of Bonn, Bonn, Germany;8. Medical Faculty, Deanery of Medicine, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany;9. Department of Internal Medicine I, Paracelsus Medical University/Salzburger Landeskliniken, Salzburg, Austria;10. Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria;11. Cologne Center of Genomics, University of Cologne, Cologne, Germany;12. Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;13. Department of Neurology, University Hospital Bonn, Bonn, Germany;14. German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany;15. Center for Clinical Trials, University of Lübeck, Lübeck, Germany;p. School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa;q. West German Heart and Vascular Center, Department of Cardiology, University Hospital of Essen, Essen, Germany;1. Tufts Medical Center, Boston, MA;2. University of California, San Francisco, San Francisco, CA;3. University of Minnesota, Minneapolis, MN;4. Centers for Disease Control and Prevention, Atlanta, GA;5. Stanford University, Stanford, CA;6. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ;7. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD;8. Boston University, Boston, MA;9. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD |
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| Abstract: | ObjectivesThe serum levels of C-peptide, an important risk factor for cardiovascular disease (CVD), increase with age. This study aimed to investigate the association between serum C-peptide and increased risk for CVD with altered lipid metabolism in the elderly.MethodsThis was a population-based cross-sectional study that included 3091 elderly participants aged ≥65 years. Serum C-peptide and lipid levels were measured according to standard protocols. Sampling weights were used to estimate the characteristics of study participants. Stratified analysis of covariance was used to evaluate the changes in the serum lipid levels according to quartiles of serum C-peptide levels, and the linear trend was assessed using a linear model. The logistic regression model was carried out to determine the association between the serum C-peptide levels and serum lipid levels.ResultsThe results of the analysis of covariance stratified by sex and serum insulin level showed that the serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels were significantly associated with changes in the serum C-peptide levels, independent of the serum insulin level. The logistic regression analyses indicated that the serum C-peptide levels were positively associated with the serum TG levels, and negatively associated with the serum HDL-C levels. A significant dose-response association was obtained in both men and women.ConclusionsSerum C-peptide levels were strongly associated with increased serum TG and reduced HDL-C levels in the elderly. Our results suggest that serum C-peptide increases the risk of CVD via a pathway that increases TG or decreases HDL-C levels. |
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| Keywords: | Cardiovascular disease Epidemiology Dyslipidemia Risk factors Serum C-peptide |
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