莫西沙星与左氧氟沙星随机双盲对照治疗尿路感染

目的 :评价莫西沙星治疗尿路感染的有效性和安全性。方法 :随机双盲对照试验及开放试验。试验组清晨用莫西沙星 1粒和安慰剂 1粒 ,晚上 2粒安慰剂均 po ;对照组用左氧氟沙星 2粒 ,po ,bid ;开放组用莫西沙星 1粒 ,po ,qd。疗程均为 7～14d。结果 :各组有 2 2例可进行安全性评价 ,可进行疗效评价者各有 2 0 ,2 0 ,18例。治疗结束后 1d ,临床有效率分别为 90 %,95 %,94 %;细菌学有效率分别为 84 %,10 0 %,10 0 %。纸片法药物敏感试验显示莫西沙星与左氧氟沙星对致病菌的高敏率和敏感率相同 ,分别为 82 %和 10 0 %。不良反应的发生率分别为 2 3 %,2 3 %,14%。结论 :莫西沙星对敏感菌引起的尿路感染疗效确切 ,安全性好。

A randomized double-blind control trial of moxifloxacin and levofloxacin in treatment of urinary tract infections

AIM:To evaluate the efficacy and safety of moxifloxacin in the treatment of urinary tract infection. METHODS: A randomized double-blind control study (part 1) and an open label study (part 2) were conducted. In part 1, the patients in the treatment group received one moxifloxacin active tablet and one placebo tablet in the morning and two placebo tablets in the evening. The patients in the control group received two levofloxacin active tablets for 7-14 d. In part 2, the patients in the open group received one moxifloxacin active tablet po, qd for 7-14 d. RESULTS: The numbers of patients enrolled into moxifloxacin and levofloxacin group in the randomized double-blind control study and in the open study were 22, 22, 22, respectively. The numbers of patients for the efficacy analysis were 20, 20, 18, respectively. On 1 d after treatment, the clinical efficacy rates were 90 %, 95 %, 94 %, respectively; the bacterial efficacy rates were 84 %, 100 %, 100 %, respectively. Susceptibility testing showed that moxifloxacin and levofloxacin had the same high susceptibility rate and sensitivity rate, which were 82 % and 100 %, respectively. Adverse reaction rates were 23 %, 23 %, 14 % in the three groups, respectively. CONCLUSION:The results show that moxifloxacin is effective and safe in the treatment of urinary tract infection.