| 成人原发性肾病综合征的病理类型、临床特征和疗效的关系 |
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| 引用本文： | 应伟中,丘长斌,林善锬,丘传禄,李辉,曹桂山.成人原发性肾病综合征的病理类型、临床特征和疗效的关系[J].复旦学报(医学版),1989(3). |
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| 作者姓名： | 应伟中 丘长斌 林善锬 丘传禄 李辉 曹桂山 |
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| 作者单位： | 上海医科大学华山医院内科肾病组
(应伟中，丘长斌，林善锬，丘传禄)，浦东中心医院
(李辉)，宜川街道医院(曹桂山) |
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| 摘 要： | 在175例经肾穿刺明确诊断的成人原发性肾病综合征中,分析其病理类型及临床表现,实验室检查和疗效的关系。肾病综合征疗效和病理类型关系密切,微小病变性肾病和局灶增生性肾炎的缓解率分别达96.3％和83.3％,而局灶性肾小球硬化症和膜增生性肾炎则分别为21.4％和23.76％,膜性肾病为48.1％。肾病综合征伴血尿,尿纤维蛋白降解产物阳性和非选择性蛋白尿者,疗效显著地差,p<0.001。
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| 关 键 词： | 肾病综合征 肾活组织检查 尿蛋白选择性 |
CORRELATION BETWEEN CLINICAL FEATURES PATHOLOGICAL TYPE AND THERAPEUTIC EFFECTS IN 175 ADULT CASES OF IDIOPATHIC NEPHROTIC SYNDROME |
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| Ying Weizhong,Qiu Changbing,Li Hui,Ling Shanyan,Qiu Chuanlu.CORRELATION BETWEEN CLINICAL FEATURES PATHOLOGICAL TYPE AND THERAPEUTIC EFFECTS IN 175 ADULT CASES OF IDIOPATHIC NEPHROTIC SYNDROME[J].Fudan University Journal of Medical Sciences,1989(3). |
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| Authors: | Ying Weizhong Qiu Changbing Li Hui Ling Shanyan Qiu Chuanlu |
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| Abstract: | The correlation between clinical manifestations, laboratory findings pathological type and therapeutic effect with corticoid immunosuppressant in 175 cases of idiopathio nephrotic syndrome (INS) was studied. The therapeutic effect had a close relation to pathological type of INS. Minimal change nephropathy (MGN) and focal paoliferative GN (FGN) responded best to therapy. Complete and partial remissions were induced in 96.3% and 83.3% of patients, respectively. The next in order were diffuse, mesangial proliferative GN(MsPGN), membranous nephropathy (MN) and IgA GN. The poorest response to therapy was focal segmental glomerulo-selerosis (FSGS) and membroproliferative GN (MPGN). the remission rates were 21.4% and 23.7%, respectively. Oases with hematuria, positive urine FDP and non-selective prote.inuria ha-d a poorer response to therapy than those without hematuria, with negativeunrine FDP and selective proteinuria. |
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| Keywords: | nephrotic syndrome renal biopsy seleetivity of proteinuria |
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