Fixed-interval schedules for drug self-administration in the rat |
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| Authors: | William A Corrigall Kathleen M Coen |
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| Institution: | (1) Addiction Research Foundation, 33 Russell Street, M5S 2S1 Toronto, Ontario, Canada;(2) Department of Physiology, University of Toronto, M5S 1A8 Toronto, Ontario, Canada |
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| Abstract: | The practicality of using second-order fixed-interval schedules in studies of heroin reinforcement with rats was examined. Optimum rates of responding were obtained with a dose of 0.03 mg/kg/infusion and an interval duration of 3 min. In addition, schedules consisting of a only a single interval were shown to be practical, leading to response rates comparable to those obtained with cocaine or food as reinforcer.The views expressed in this publication are those of the author and do not necessarily represent those of the Addiction Research Foundation |
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| Keywords: | Fixed-interval Self-administration Second-order schedule Heroin Cocaine |
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