Cardiac arrhythmogenic action of benzo(a)pyrene in the rabbit |
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Authors: | Gary P Carlson James F White |
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Institution: | Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 49707 U.S.A. |
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Abstract: | Rabbits treated with benzo(a)pyrene developed cardiac arrhythmias when exposed by inhalation to 8100 ppm trichloroethylene or 15000 ppm halothane to a greater extent and at lower doses of epinephrine challenge than did controls. Benzo(a)pyrene and 3-methylcholanthrene both increased the metabolism of trichloroethylene, but 3-methylcholanthrene did not increase its cardiotoxic effect. The basis of the arrythmogenic action of benzo(a)pyrene appears to be unrelated to its ability to induce xenobiotic metabolism. |
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Keywords: | Trichloroethylene 3-methylcholanthrene halothane phenobarbital |
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