蛇床子挥发油与其它促透剂合用促透效果研究

目的：研究蛇床子挥发油与其它促透剂合用的促透效果。方法：在离体透皮吸收实验装置上，采用离体兔皮用1％蛇床子挥发油、5％油酸、1％蛇床子挥发油＋5％油酸和1％氮酮预处理后作透皮吸收试验。结果：1％蛇床子挥发油、5％油酸、1％蛇床子挥发油＋5％油酸和1％氮酮，对1％双氯芬酸钠都有良好的促透作用（与对照组比较P＜0.01），1％蛇床子挥发油比1％氯酮促透作用强1.6倍，但1％蛇床子挥发油和5％油酸合用，与1％蛇床子挥发油、5％油酸的促透效果比较差异无显著性（P＞0.05）。结论：蛇床子挥发油具有良好的促透效果，但其与油酸无协同作用。

Study on Effect of Essential Oil from Cnidium monnieri (L.) Cuss. Enhancing the Skin Penetration with Other Transdermal Enhancer

Objective:To investigate the effect of essential oil from Cnidium monnieri (L.) Cuss. (EOCMC) enhancing the skin penetration with other transdermal enhancer. Methods: The test of transdermal absorption was made on instrument of vitro skin penetration by employed rabbit skin that pretreated by 1% EOCMC, 5% oleic acid, 1% EOCMC plus 5% oleic acid and 1% azone. Results: The all groups had good effects on enhancing the transdermal absorption of 1% diclofenac sodium (P<0.01 when compare with control group). The transdermal enhancing effect of 1% EOCMC was 1.6 times higher than 1% azone. There was no significant difference when compared the effect of 1% EOCMC plus 5% oleic acid with 1% EOCMC or 5% oleic acid (P> 0.05). Conclusion: EOCMC had a better effect on enhancing the transdermal absorption. There was no synergism when it was used together with 5% oleic acid.