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| 儿童急性白血病Th1和Th2细胞因子的临床研究 | |
| 引用本文： | 王丽,刘家应,夏敏,蒋慧. 儿童急性白血病Th1和Th2细胞因子的临床研究[J]. 上海交通大学学报(医学版), 2011, 31(11): 1657-1660. DOI: 10.3969/j.issn.1674-8115.2011.11.033 |
| 作者姓名： | 王丽 刘家应 夏敏 蒋慧 |
| 作者单位： | 1. 上海交通大学附属儿童医院血液肿瘤科,上海,200040 2. 上海交通大学附属儿童医院检验科,上海,200040 |
| 摘 要： | 目的研究急性白血病患儿外周血中Th1和Th2细胞因子的表达及其在白血病发病及化疗过程中的意义。方法收集78例急性白血病患儿,其中急性淋巴细胞白血病(ALL)53例,急性非淋巴细胞白血病(ANLL)25例;21例为初诊患者(初诊组)。所有患儿经化疗后分为两组:缓解组1(n=42),完全缓解期(CR)<12个月;缓解组2(n=36),CR≥12个月。另设30名健康儿童为正常对照组。采用流式细胞术测定外周血Th1(IL-2、IFNγ)和Th2(IL-4)细胞因子的百分比。结果初诊组治疗前的IL-2、IFNγ和IL-4表达水平与正常对照组和缓解组比较,差异均有统计学意义(P<0.05);治疗后表达水平显著改善,与正常对照组比较差异无统计学意义(P>0.05)。缓解组1的IL-2和IFNγ表达水平均显著高于缓解组2(P<0.05),但IL-4表达水平差异无统计学意义(P>0.05);两组患儿的3种细胞因子表达水平与正常对照组比较差异均无统计学意义(P>0.05)。ALL与ANLL患儿的3种细胞因子表达水平比较,差异均无统计学意义(P>0.05)。结论 Th1和Th2细胞因子可能参与了急性白血病的发病,在ALL与ANLL发病过程中的作用可能相同;随着缓解时间延长,患者的免疫功能逐渐恢复,后期再次紊乱,可能与化疗继发的免疫抑制有关。 |
| 关 键 词： | 急性白血病 辅助性T淋巴细胞 流式细胞术 儿童 |
Clinical research on Th1 and Th2 cytokines in children with acute leukemia |
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| WANG Li,LIU Jia-ying,XIA Min,JIANG Hui. Clinical research on Th1 and Th2 cytokines in children with acute leukemia[J]. Journal of Shanghai Jiaotong University:Medical Science, 2011, 31(11): 1657-1660. DOI: 10.3969/j.issn.1674-8115.2011.11.033 | |
| Authors: | WANG Li LIU Jia-ying XIA Min JIANG Hui |
| Affiliation: | WANG Li1,LIU Jia-ying2,XIA Min2,JIANG Hui1(1.Department of Hematology,2.Department of Laboratory,Shanghai Children's Hospital,Shanghai Jiaotong University,Shanghai 200040,China) |
| Abstract: | Objective To investigate the expression of Th1 and Th2 cytokines in peripheral blood of children with acute leukemia,and explore its roles in the onset and chemotherapy of leukemia.Methods Seventy-eight children with acute leukemia were enrolled,including 53 cases of acute lymphoblastic leukemia(ALL) and 25 cases of acute nonlymphocytic leukemia(ANLL).Twenty-one cases were newly diagnosed(newly diagnosed group).All cases were divided into complete remission group 1(n=42,duration of complete remission<12 mon... |
| Keywords: | acute leukemia helper T cell flow cytometry childhood |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |