阿托伐他汀对急性冠脉综合征患者炎性因子浓度的影响

目的研究应用阿托伐他汀（atorvastatin）对急性冠状动脉综合征（acute coronary syn-dromes，ACS）患者减少炎症反应、稳定斑块的作用。方法选定ACS患者60例，稳定型心绞痛（SA）患者30例及正常对照组30例。随机将ACS患者分为阿托伐他汀治疗组（30例）和常规治疗组（30例），比较各组间血清白介素石（IL-6）、白介素-8（IL-8）及超敏C反应蛋白（sCRP）的水平变化。结果ACS组与SA组及正常对照组之间血清IL-6、IL-8及sCRP水平相比差异有统计学意义，两治疗组治疗后血清IL-6、IL-8及sCRP水平相比差异有统计学意义。结论阿托伐他汀可降低ACS患者血清IL-6、IL-8及sCRP水平，减少冠状动脉粥样斑块基质成分的降解和炎症反应，从而起到稳定动脉粥样硬化斑块的作用。

The effect of atorvastatin on serum level of interleukin-6,interleukin-8 and super C-reactive protein in patients with acute coronary syndromes

Objective To investigate the influences of atorvastatin on serum interleukin-6,interleukin-8 and super C-reactive protein levels in patients with acute coronary syndrome(ACS).Methods There were 60 patients with ACS and 30 patients with SA,Meanwhile,30 cases of age matched control individuals were selected.Then 60 patients with ACS were randomly divided into two groups:Atorvastatin treatment group and regular treatment group.The serum level of interleukin-6,interleukin-8 and super C-reactive protein were compared among all groups.Results There was significant difference in serum level of interleukin-6,interleukin-8 and super C-reactive protein between ACS group and SA group and control group.There was significant difference in serum level of interleukin-6,interleukin-8 and super C-reactive protein between atorvastatin treatment group and regular treatment group after treatment.Conclusion Atorvastatin could decrease the breakdown of matrix collagen and reduce inflammatory reaction,and it might have a beneficial effect on steadying the plaque.