A case-control for the association between change in weight,family history and hypertension at different ages

To study the association between the changes of weight, family history and hypertension at different ages, a pair-matched case-control study was conducted in the outpatient service of department of internal medicine in Binjiang Hospital of Tianjin from 1994 to 1996. The cases were selected from 312 patients with hypertension diagnosed during 1994-1996 and identified newly in the survey. The controls were selected from other outpatients of no cardiovascular disease histories matched by age and sex. The conditional logistic regression model was used. The cases and controls were divided into two age groups under 59 years old, 60 and older. History of hypertension in the first degree-relatives was linked to hypertension, but family history of hypertension of groups under age 59, and at 60 and older was mainly hypertension history of parents and siblings, respectively. Other risk factors of developing hypertension were higher weight or body mass index (kg/m2) in the survey, higher degree of weight gain in comparison with the basic weight and early age at beginning weight gain in all two groups. However, the risk of developing hypertension for increasing weight and obesity increased with advancing age groups. The study further indicates that controlling body weight, decreasing the degree of weight gain, and delaying the beginning age of weight gain all contribute to the lower risk of suffering from hypertension and were effective measures of hypertension of the prevention and cure.