| 中国汉族人群2型糖尿病与脂联素基因SNP-11377位点相关性的Meta分析 |
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| 引用本文： | 李显丽,张瑛,杨莹,姚宇峰,史荔,杨曼,陶文玉,熊煜欣,李奕平.中国汉族人群2型糖尿病与脂联素基因SNP-11377位点相关性的Meta分析[J].中华糖尿病杂志,2012(8):561-564. |
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| 作者姓名： | 李显丽 张瑛 杨莹 姚宇峰 史荔 杨曼 陶文玉 熊煜欣 李奕平 |
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| 作者单位： | 云南省第二人民医院内分泌代谢科;中国医学科学院北京协和医学生物学研究所 |
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| 基金项目： | 云南省教育厅科学研究基金(09C0296);云南省科技厅-昆明医学院应用基础研究联合专项基金(2011FB226) |
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| 摘 要： | 目的评价脂联素基因SNP-11377位点与T2DM的相关性。方法采用Meta分析评估SNP-11377位点与T2DM的相关性。异质性检验后采用M-H固定效应模型合并比值比(OR)值,并进行发表偏倚检验。结果 (1)共纳入10篇文献,其中病例组2831例、对照组3035例。(2)异质性检验显示,脂联素基因SNP-11377在各研究间是同质(I2=11.2%,P>0.05),各研究之间不存在异质性。(3)M-H固定效应模型进行数据合并,结果显示合并OR为1.09(95%CI为1.00～1.18,P=0.05)。(4)Begg和Egger偏倚分析均显示无明显发表偏倚。结论脂联素基因SNP-11377G等位基因可能与中国汉族人群T2DM的发病风险相关。
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| 关 键 词： | 糖尿病 2型 脂联素基因 单核苷酸多态性 Meta分析 |
A Meta-analysis on the association between adiponectin gene SNP-11377 and type 2 diabetes in Chinese Han population |
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| Institution: | LI Xian-li,ZHANG Ying,YANG Ying,et al.Department of Endocrinology and Metabolism,The Second People’s Hospital of Yunnan Province,Kunming 650021,China |
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| Abstract: | Objective To investigate the association of SNP-11377 in adiponectin gene with type 2 diabetes mellitus(T2DM).Methods The Meta-analysis was performed to assess the association of SNP-11377 in adiponectin gene with T2DM.Fixed effect model(M-H) was used to pool odd ratio(OR) after heterogeneity test,while the publication bias was calculated.Results(1) Ten case-control studies were included in the Meta-analysis,with a total of 2831 T2DM patients and 3035 controls.(2) The between-study heterogeneity of the adiponectin gene SNP-11377 was not significant(I2=11.2%,P>0.05).(3) All data were pooled by Fixed effect model and showed total OR=1.09(95%CI:1.00～1.18,P=0.05).(4) Publication bias was examined by the Begg’s funnel plot and Egger’s test and no publication bias was observed.Conclusion SNP-11377 G allele may be associated with the increased T2DM risk in Chinese Han population. |
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| Keywords: | Diabetes mellitus Type 2 Adiponectin gene Single nucleotide polymorphism Meta-analysis |
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