Identification of three cannabimimetic indazole and pyrazole derivatives,APINACA 2H‐indazole analogue,AMPPPCA, and 5F‐AMPPPCA |
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Abstract: | This paper reports analytical properties of three cannabimimetic indazole and pyrazole derivatives seized from a clandestine laboratory. These three new synthetic cannabinoids include N ‐(1‐adamantyl)‐2‐pentyl‐2H ‐indazole‐3‐carboxamide (APINACA 2H ‐indazole analogue, 1 ), N ‐(1‐adamantyl)‐4‐methyl‐1‐pentyl‐5‐phenyl‐1H ‐pyrazole‐3‐carboxamide (AMPPPCA, 2 ), and N ‐(1‐adamantyl)‐1‐(5‐fluoropentyl)‐4‐methyl‐5‐phenyl‐1H ‐pyrazole‐3‐carboxamide (5F‐AMPPPCA, 3 ). These compounds were identified by liquid chromatography‐quadrupole time‐of‐flight‐mass spectrometry (LC‐QTOF‐MS), gas chromatography‐time‐of‐flight‐mass spectrometry (GC‐TOF‐MS), and nuclear magnetic resonance (NMR) spectroscopy. No analytical properties and pharmacological activities about compounds 1–3 have appeared until now, making this the first report on these compounds. Copyright © 2016 John Wiley & Sons, Ltd. |
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Keywords: | new psychoactive substance synthetic cannabinoid APINACA 2H‐indazole analogue AMPPPCA 5F‐AMPPPCA |
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