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Acute T-cell leukemia/lymphoma mimicking Hodgkin's disease with secondary HTLV I seroconversion
Authors:F Picard  F Dreyfus  M Le Guern  M Tulliez  L d'Auriol  S Neron  F Galibert  S Saragosti  B Varet
Institution:Department of Hematology, H?pital Cochin, France.
Abstract:The authors observed a pleiomorphic lymphoma mimicking Hodgkin's lymphoma in a French Guyana black woman lacking antibodies for human T-cell lymphoma/leukemia virus type I (HTLV I). After two courses of chemotherapy with either mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) or doxorubicin, bleomycin, vincaleukoblastine, and dacarbazine (ABVD), a typical acute T-cell leukemia/lymphoma developed with HTLV I seroconversion. Specific HTLV I DNA sequences were detected using the polymerase chain reaction (PCR) on a lymph node biopsy obtained before chemotherapy. The mechanisms of the seroconversion are discussed.
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