血浆肿瘤坏死因子-α、白细胞介素-6和内皮素在高血压合并糖耐量异常患者中的变化及其意义

目的:观察原发性高血压(EH)合并糖耐量异常(IGT)患者血浆肿瘤坏死因子-α(tumornecrosisfactor-alpha,TNF-α)和白细胞介素-6(interleukin-6,IL-6)及内皮素(ET)水平的变化。方法:入选EH患者82例,其中合并IGT者42例,糖耐量正常(NGT)者40例;同时随机挑选血压正常健康人(NT)40例为NT组作为对照。采用ELISA法测定血浆中TNF-α、IL-6含量。结果:EH组血浆TNF-α、IL-6、ET明显高于NT组[TNF-α,EH组(27.80±4.73)ng/mL,NT组(23.83±2.28)ng/mL,P<0.05;IL-6,EH组(90.62±18.09)ng/mL,NT组(76.76±12.81)ng/mL,P<0.05;ET,EH组(39.46±10.77)ng/mL,NT组(30.92±4.0)ng/mL,P<0.01]。多因素logistic回归分析,EH合并IGT与TNF-α、IL-6、FPG、2hPG呈正相关(β为1.247、1.180、0.516、0.140,均P<0.05)。结论:EH合并IGT患者血浆TNF-α、IL-6、ET增高,提示EH合并IGT患者体内炎症反应进一步增加及ET水平进一步升高。

Serum Tumor Necrosis Factor-alpha, interleukin6 and endothelin Levels in hypertensive patients with impaired glucose tolerance

Objective To observe the changes of levels of serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and endothelin (ET) in patients with essential hypertension (EH) and impaired glucose tolerance (IGT). Methods Eighty-two patients with EH were enrolled and divided into two groups (IGT: 42 cases; NGT: 40 cases). Forty healthy normotensive (NT) persons were served as controls. The serum level of TNF-α, IL-6 and ET were measured by enzyme-linked immunosorbent assay (ELISA). Results TNF-α, IL6 and ET were significantly increased in EH group compared to NT group. [TNF-α: (27.80 ± 4.73) μmol/L vs (23.83 ± 2.28) μmol/L, P < 0.05; IL-6: (90.62 ± 18.09) μmol/L vs (76.76 ± 12.81) μmol/L, P < 0.05; ET: (39.46 ± 10.77) ng/mL vs (30.92 ± 4.0) ng/mL, P < 0.01]. Multivariate analysis showed TNF-α, IL-6, fast plasma glucose (FPG) and 2 hours plasma glucose (2hPG) were predisposing risk factors for hypertensive patients with IGT (β = 1.247, 1.180, 0.516 and 0.140, respectively; P < 0.05 for all). Conclusion The concentrations of TNF-α, IL6 and ET were increased in hypertensive patients with IGT, indicating that enhanced inflammatory reaction exist in EH patients combined with IGT.