血清CA125,CA19-9联合检测在慢性乙型肝炎肝硬化早期诊断中的意义

目的检测慢性乙型肝炎患者血清CA125,CA19-9表达水平,探讨对早期肝硬化的诊断意义.方法慢性乙型肝炎患者94例,肝活检病理诊断显示53例合并早期肝硬化,41例无肝硬化改变.健康体检者30例作为对照组.采用微粒子酶免分析法(MEIA)分别检测受试者血清CA125,CA19-9水平.结果慢性乙肝患者血清CA125与CA19-9水平显著高于正常对照组,其中伴有肝硬化病理改变组显著高于无肝硬化病理改变组.伴有肝硬化病理改变的慢性乙肝患者血清CA125与CA19-9阳性率分别为49.1%,35.6%,显著高于无肝硬化病理改变组及正常对照组.伴有肝硬化病变组血清CA125与CA19-9水平有任一项增高阳性率为67.7%,显著高于单纯血清CA125和CA19-9的阳性率.结论血清CA125,A19-9检测有助于慢性乙肝患者早期肝硬化发现,血清CA125,A19-9联合检测较单纯CA125和CA19-9检测更为敏感.

The Significance of Combined Mesurement of Serum CA125 and CA19-9 in the Early Diagnosis of Hepatocirrhosis in Patients with Chronic Hepatitis B

Objective To investigate the significance of serum CA125 and CA19-9 detection in early diagnosis of hepatocirrhosis in patients with chronic hepatitis B.Methods Experiment group consisted of 94 patients with chronic hepatitis B had been done liver biopay,53 patients were with early hepatocirrhosis and 41 patients were without. Control group consisted of 30 healthy volunteers. Serum CA125 and CA19-9 levels were determined with MEIA. Results The levels of serum CA125 and C19-9 in patients with chconic hepatitis B increased significantly than those in healthy controls, which in patients with hepatocirrhosis were significantly higher compared to the patients without hepatocirrhosis. The positive rates of serum CA125 and CA19-9 in patients with hepatocirrthosis were separately 49.1% mM 35.6%, significantly higher than those in patients of chronic papatitis B without hepatocirrhosis.The combined positive rate of CA19-9 and CA125 was higher significantly than the positive rate of single CA125 or Ca19-9. Conclusion Serum CA125 or CA19-9 measurement can be beneficial to the early detection of hepatocirrhosis in patients of chronic hepatitis B. Combined detection of serum CA19-9 and CA125 could be more sensitive.