血浆抗凝物质及花生四烯酸代谢产物在高脂血症患者的临床意义

目的:研究血浆抗凝物质及花生四烯酸代谢产物在高脂血症患者的临床意义。方法:临床诊断的高脂血症患者与正常对照组进行比较,其中抗凝血酶 Ⅲ抗原(AT- Ⅲ:Ag)、α1 抗胰蛋白酶(α1 - AT)和α2 巨球蛋白(α2 - MG)采用免疫浊度法;抗凝血酶Ⅲ活性(AT -Ⅲ:A)用发色底物法;血栓烷B2 (TXB2 )和6 - 酮前列腺素F1α(6 - K PGF1α)用放射免疫法。结果:患者组AT Ⅲ:Ag与正常对照组比较无差异(P >0 .0 5 ) ,但AT Ⅲ:A与正常组比较降低,α1 - AT无差异,α2 - MG有显著意义增高(P <0 .0 5 ) ,患者组TXB2 与正常组比较明显增高而6- K PGF1α明显降低(P <0 .0 1 )。结论:抗凝指标降低(AT- Ⅲ:A)示高凝状态,TXB2 和6 - K PGF1α的改变是高脂血症患者的危险因素,对于患者病理意义的研究是有帮助的,也显示患者极易发生动脉硬化的原因。

Significance of Plasmatic Anticoagulation Substance and Metabolic Products of Arachidonic Acid in Patient with Hyperlipoidemia

Objective To investigate the significance of plasmaanticoagulation substance and with hyperlipidemia.Method the diagnostic data of hyperlipoidemia and compared with of normal subjects antithrombin Ⅲantigen(AT-Ⅲ:Ag),α_1-Antitrypsin(α_1-AT)and α_2-megaglobulin(α_2-MG)were Immuno-turbidity assay;antithrombin-Ⅲ activity(AT-Ⅲ:A) were CPS assay;thromboxineB_2(TXB_2) and 6-Keto-prostaglandin F_ 1α(6-K-PGF_ 1α)were RIA.Result patientgroup AT-Ⅲ:Ag and compared with of normal subjects there is no different(P>0.05)but AT-Ⅲ:A were lower that those in normal subjects α_1-ATthere is no different(P>0.05);α_2-MG showed that mild higher(P<0.05);TXB_2 in patient groupwere markedly higer(P<0.01) than that in normal subjectsbut 6-K-PGF_ 1αmarkedly lower significantly.Conclusion the result shows that the decrease of anticoagulation indexes(AT-Ⅲ:A) indicates the state of hypercoagulabilityand the changes of TXB_2 and 6-K-PGF_ 1α were dangerous factor for hyperlipoidemiamay be helpful in explore the pathology significance of hyperlipoidemia and itcan be look as the cause of atherosclerosis of hyperlipoidemia.