��ͯ�������Ʋ�����ι���������о�

目的探究儿童哮喘控制测试(C-ACT)评分与哮喘患儿肺功能及气道反应性的相关关系。方法对2009年10月至2010年5月在重庆医科大学附属儿童医院哮喘门诊就诊的273例哮喘患儿,测量肺功能并同时完成C-ACT评分,以第1秒用力呼气流量占预计值百分比(FEV1%)和最大呼气流量占预计值百分比(PEF%)作为通气功能指标与C-ACT进行相关性分析;根据乙酰甲胆碱激发实验将气道反应性分为重度、中度、轻度和极轻度4级,比较各级间C-ACT得分及大小气道通气功能指标的差异,研究C-ACT与通气功能及气道反应性的关系。结果 C-ACT与FEV1%、PEF%的相关系数分别为0.25和0.34(P<0.01),去除就诊前4周患上呼吸道感染和小于7岁的患儿后,其相关系数分别为0.42和0.52(P<0.01);气道反应性重度和极轻度组间C-ACT得分差异有统计学意义(P<0.01),中度和轻度组间差异无统计学意义(P>0.05)。结论 C-ACT评分与哮喘患儿通气功能、气道反应性有较好的相关性,就诊前4周内是否患有上呼吸道感染和年龄是影响其相关性的两个主要因素。

Research into the correlation between childhood asthma control test and lung function

Objective To investigate relationship between childhood asthma control test(C-ACT)and lung function.Methods During the clinic visit,273 asthma patients completed the Chinese version of C-ACT and underwent spirometric measurments at the same time.The correlation between C-ACT with FEV1% and PEF% were analyzed.The patients were categorized into 4 groups based on the degree of airway responsiveness(AR),1)severe group(PC20=0.5mg/mL),2) moderate group(PC20= 2mg/mL),3) mild group(PC20=8mg/mL),4) minimal group(PC20=16mg/mL),and then the relationships between C-ACT score and AR as well as ventilation function of each group were assessed by one-way ANOVA.Results Significant correlation was observed between C-ACT score and FEV1%(r = 0.25;P<0.01),PEF%(r = 0.34;P<0.01).When the patients less than 7 years or suffering upper respiratory tract infection(URI) 4 weeks before seeing the doctor were excluded,C-ACT score demonstrated good correlations with PEF%(r = 0.52;P<0.01) and moderate correlations with FEV1%(r = 0.42;P<0.01).C-ACT score difference had statistical significance between severe group and minimal group(mean [SD]:21.7 [2.4] vs.23.6 [2.5];P<0.01),but no significant difference between moderate group and mild group.Conclusions There is moderate correlations between C-ACT score and ventilation function and AR,and being less than 7 years or suffering URI 4 weeks before seeing the doctor may be two factors that influence this relationship.