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| 胃癌单克隆抗体GL—013对应抗原的免疫电镜分布观察 | |
| 引用本文： | 袁媛 林慧芝 等. 胃癌单克隆抗体GL—013对应抗原的免疫电镜分布观察[J]. 中国医科大学学报, 1990, 19(1): 6-8 |
| 作者姓名： | 袁媛 林慧芝 等 |
| 作者单位： | 中国医科大学胃癌研究室(袁媛，林慧芝，张佩范)，中国医科大学胃癌研究室(王梅先) |
| 摘 要： | 运用酶标免疫电镜技术,对16例不同类型胃癌进行了胃癌单克隆抗体GL-013对应之抗原的超微结构水平分布观察。证实了GL-013抗原在胃癌细胞及癌旁“正常”粘膜分布的差异,首次提出该抗原可能是一种可溶性胃癌相关抗原,可做为胃癌研究及血清学诊断的免疫指标之一。 |
| 关 键 词： | 免疫电镜技术 单克隆抗体 胃癌 |
THE ULTRASTRUCTURAL DISTRIBLTICN OF THE ANTIGEN ASSOCIATED WITH MONOCLONAL ANTIBODY(GL-013) IN THE GASTRIC CANCER |
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| Yuan Yuan,et al Cancer Institute. THE ULTRASTRUCTURAL DISTRIBLTICN OF THE ANTIGEN ASSOCIATED WITH MONOCLONAL ANTIBODY(GL-013) IN THE GASTRIC CANCER[J]. Journal of China Medical University, 1990, 19(1): 6-8 | |
| Authors: | Yuan Yuan et al Cancer Institute |
| Abstract: | The ultrastructural distribution of the antigen assoociated with monoclonalantibody (GL-013) in 16 cases of gastric cancer was studied by immunoelectronmicroscopy. The results of our research showed that there was a little GL-013antigen in the microvilli of normal opithclium or distrituted regularly along thesurface of cells. In gastric cancer, GL-013 antigen was detected more heavy andirregularly over the entire membrane of cancer cells and also found in theprotein-synthetic and transport intracellular structure of cancer cells. The abnomaldistribution of GL-013 antigen in gastric cancer showed that GL-013 antigencould be used as an immunccytological marker in the research on gastric cancer.In addition, it showed that GL-013 antigen might be a soluble one associatedwith the gastric cancer. Therefor, GL-013 antigen can be used as a marker in the serodiagnosis of gastric cancer. |
| Keywords: | immunoeleronmicroscopy Mencelenal antibody gastric cancer |
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