Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteins |
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| Authors: | T. Yamada P. L. McGeer E. G. McGeer |
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| Affiliation: | (1) Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia Vancouver, B.C., Canada;(2) Neurodegenerative Diseases Centre, University of British Columbia Vancouver, B.C., Canada;(3) University of B.C., 2255 Westbrook Mall, V6T 1Z3 Vancouver, B.C., Canada |
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| Abstract: | Summary The substantia nigra (SN) in 11 Parkinson's disease (PD) patients and 5 neurologically normal controls was examined immunohistochemically using antibodies to various proteins of the complement system. In PD, but not in control SN, intra-and extraneuronal Lewy bodies and dendritic spheroid bodies were stained with anti-human C3d, C4d, C7 and C9 antibodies, but not with antibodies to C1q, fraction Bb of factor B or properdin. Axonal spheroid bodies in the nigrostriatal tract were not stained by any of the complement antibodies. However, complement-activated oligodendroglia were revealed by anti-C3d and anti-C4d antibodies in the PD substantia nigral area. These data indicate that some pathological structures in PD activate the classical complement pathway.Supported by grants from the Medical Research Council of Canada and the Parkinson's Disease Foundation of Canada, as well as donations from individual British Columbians. |
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| Keywords: | Parkinson's disease Complement Lewy bodies Oligodendrocytes |
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