胎儿生长受限孕妇血浆活化蛋白c抵抗与抗心磷脂抗体检测结果分析

目的:研究活化蛋白c抵抗(APCR)、抗心磷脂抗体(ACA)与胎儿生长受限(FGR)的相关性,并进一步探讨FGR患者APCR与ACA的关系。方法:采用APTT±APC法检测20例原因不明FGR患者(实验组)、35例正常待产妇(对照组)的APCsr;Elisa方法检测ACA-IgG、IgM滴度水平。结果:①实验组APCR阳性率60.0%,明显高于对照组(31.4%),P(0.05;②实验组ACA阳性率20.0%,对照组2.9%,差异有显著性;③APCR阳性组ACA阳性3例,阴性组ACA阳性2例,无显著差异。结论:APCR和ACA均是FGR的危险因素,但获得性APCR的发生并非ACA抑制蛋白c通路导致凝血异常及导致FGR形成的唯一通路。

Relationship between the activated protein C resistance and anticardiolipin antibodies in patients with fetal growth restriction

Objective:To examine the activated protein C sensitive ratio and the presence of anticardiolipin antibodies in pregnancies complicating with fetal growth restriction to explore the mechanism of fetal growth restriction.Methods:An activated partial thromboplastin time(APTT)-based assay for APCsr and ELISA for ACA of 20 pregnancies with idiophathic fetal growth restriction and 35 normal pregnancies.Results:The incidence of APCR and ACA in FGR group was higher than normal pregnant women's,and the difference was significant(P0.05).Conclusion:The presence of either activated protein C resistance or ACA may contribute to risk of fetal growth restriction.There is not a significant interaction between APCR and ACA in pregnancies with fetal growth restriction.