熊去氧胆酸与多烯磷脂酰胆碱治疗非酒精性脂肪性肝病的临床效果观察

目的 探讨熊去氧胆酸与多烯磷脂酰胆碱治疗非酒精性脂肪性肝病的临床效果.方法 收集2012年5月～2013年11月我院住院及门诊治疗的122例NAFLD患者,按照入院治疗的先后顺序分为观察组和对照组,每组61例.对照组采用多烯磷脂酰胆碱治疗,观察组采用熊去氧胆酸联合多烯磷脂酰胆碱治疗,比较两组总有效率及治疗前后肝功能、血脂及肝与脾CT比值.结果 ①观察组总有效率为83.61％,对照组为63.93％,观察组明显高于对照组（P＜0.05）.②两组治疗后ALT、AST、γ-GT、TG、TC均明显低于治疗前,HDL-C明显高于治疗前,观察组治疗后肝与脾CT比值明显高于治疗前（P＜0.05）.观察组治疗后ALT、AST、γ-GT、TG、TC均明显低于对照组,而HDL-C明显高于对照组（P＜0.05）.结论 采用熊去氧胆酸与多烯磷脂酰胆碱治疗NAFLD的临床效果明显优于单独使用多烯磷脂酰胆碱.

The clinical effect of ursodeoxycholic acid and polyene phosphatidylcholine in the treatment of non-alcoholic fatty liver disease

Objective To investigate the clinical effect of ursodeoxycholic acid and polyene phosphatidylcholine of non-alcoholic fatty liver disease. Methods A total of 122 cases of NAFLD patients were collected from May 2012 to November 2013 in our hospital inpatient and outpatient treatment, according to the order of hospitalization they were divided into observation group and control group, there were 61 cases in every group. The control group was given polyene phosphatidylcholine treatment, the observation group was given UDCA combined with polyene phosphatidylcholine treatment. We compared total liver function, blood lipids, liver and spleen CT ratio and efficiency before and after treatment. Results （1） Total efficiency of observation group was 83.61%, the control group was 63.93% the observation group was significantly higher than the control group （P〈0.05）. （2） After treatment, ALT, AST, ＂,/-GT, TG, TC of two group were significantly lower than before treatment, HDL-C was significantly higher than before treatment, after treatment, the liver and spleen CT of observation group was significantly higher than pre-treatment CT （P〈0.05）. ALT, AST, ~/-GT, TG, TC of the observation group after treatment were significantly lower than the control group after treatment, while HDL-C was significantly higher （P〈0.05）. Conclusion Ursodeoxycholic acid and potyene phosphatidylcholine NAFLD clinical treatment is better than alone polyene phosphatidylcholine effect.